Obstructive sleep apnea (OSA) has been linked to placenta-mediated outcomes such as preeclampsia.
The aims of this project are to understand the association of OSA with abnormalities in placental histopathology and function, reflected in alterations in placenta-secreted markers that have been linked to the development of preeclampsia, and to evaluate the effect that treatment of OSA will have on placental morphology and function. To meet these aims, the project plans to recruit women at risk for OSA, screen them with home sleep apnea testing and enroll those with a positive diagnosis of OSA to participate in this project. At enrollment women will have baseline clinical risk assessment and measurement of circulating markers. These women will then be randomized to receive positive airway pressure therapy (accepted therapy for OSA in the non-pregnant population) or nasal strips (placebo). The urn randomization method utilized in this project will optimize the chance of having a similar distribution of OSA severity in the two groups. Women in both groups will receive intensive training and frequent monitoring of compliance, remotely for positive airway pressure group, and by phone calls and monitoring of need for refills in the nasal strips group. Circulating markers and blood pressure measurements will be repeated in the second and third trimester and compared in both groups. Sleep quality assessment with questionnaires and actigraphy will be performed in the first and third trimester since sleep quality may be a potential confounder of outcomes. At the time of delivery, women will have their placentas collected for microscopic tissue examination and for staining that will identify th same circulating markers in placental tissue and to demonstrate that the source of these markers is the placenta rather than other tissues. Understanding the mechanisms linking OSA and preeclampsia will facilitate efforts to identify women at risk for adverse outcomes such as preeclampsia. Such knowledge will be used to pave the way for focused strategies in prevention and treatment of a disorder that represents a substantial financial burden and is the precursor of long- term cardiovascular and metabolic outcomes in both mothers and their children.

Public Health Relevance

Preeclampsia continues to represent a major public health concern and remains a source of substantial financial burden. The disorder impacts the health of both the mother and the offspring. Obstructive sleep apnea is another relatively common disorder that has been recently linked to preeclampsia. Given the relative ease of treatment of obstructive sleep apnea, understanding the fundamental relationships between these two disorders will facilitate efforts to identify women at risk for preeclampsia, and pave the way for focused strategies to prevent and treat this disorder.

National Institute of Health (NIH)
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Research Project (R01)
Project #
Application #
Study Section
Cardiovascular and Sleep Epidemiology (CASE)
Program Officer
Ilekis, John V
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Miriam Hospital
United States
Zip Code
Khan, Nazia; Lambert-Messerlian, Geralyn; Monteiro, Joao Filipe et al. (2018) Oxidative and carbonyl stress in pregnant women with obstructive sleep apnea. Sleep Breath 22:233-240
Bublitz, Margaret H; Bourjeily, Ghada; D'Angelo, Christina et al. (2018) Maternal Sleep Quality and Diurnal Cortisol Regulation Over Pregnancy. Behav Sleep Med 16:282-293
Pengo, Martino F; Won, Christine H; Bourjeily, Ghada (2018) Sleep in Women Across the Life Span. Chest 154:196-206
Salameh, Myriam; Lee, Jennifer; Palomaki, Glenn et al. (2018) Snoring and markers of fetal and placental wellbeing. Clin Chim Acta 485:139-143
Bublitz, Margaret H; Monteiro, Joao Filipe; Caraganis, Andrew et al. (2018) Obstructive Sleep Apnea in Gestational Diabetes: A Pilot Study of the Role of the Hypothalamic-Pituitary-Adrenal Axis. J Clin Sleep Med 14:87-93
Lee, Jennifer; Eklund, Elizabeth E; Lambert-Messerlian, Geralyn et al. (2017) Serum Progesterone Levels in Pregnant Women with Obstructive Sleep Apnea: A Case Control Study. J Womens Health (Larchmt) 26:259-265
Tan, Miranda; Bourjeily, Ghada (2017) Shaking Up Perspectives of Restless Legs Syndrome in Pregnancy. J Clin Sleep Med 13:857-858
Bublitz, Margaret; De La Monte, Suzanne; Martin, Susan et al. (2017) Childhood maltreatment and inflammation among pregnant women with gestational diabetes mellitus: A pilot study. Obstet Med 10:120-124
Bourjeily, Ghada; Danilack, Valery A; Bublitz, Margaret H et al. (2017) Obstructive sleep apnea in pregnancy is associated with adverse maternal outcomes: a national cohort. Sleep Med 38:50-57
He, M; Curran, P; Raker, C et al. (2016) Placental findings associated with maternal obesity at early pregnancy. Pathol Res Pract 212:282-7

Showing the most recent 10 out of 12 publications