Childhood adversity accounts for 50-75% of the population attributable risk for alcoholism, drug abuse, depression, and suicide. Recent work has also documented enduring effects of childhood maltreatment on adult neurobiology, including alterations in cortical and limbic structures and reprogramming of HPA-axis mediated stress responses. Notably missing, however, is an understanding of how the potential neurobiological sequelae of chronic childhood adversity shape the vital adult activity of caring for an infant, and how this in turn affects early brain development. The proposed program of research seeks, for the first time, to link processes across neurobiological, neuroendocrine, and behavioral levels to examine how the impact of early adversity is conveyed from mother to child, among 150 mothers and their infants. To accomplish these aims the program is led by multiple principal investigators with specific expertise in: (1) mother-infant communication; (2) neurobiological effects of childhood abuse and (3) neonatal neuroimaging.
The first aim of the study is to assess whether adversity- related alterations in structure, function or connectivity of maternal brain regions critical to stress regulation, including the amygdala, hippocampus/subiculum, and medial orbitofrontal cortex (MOFC), are associated with differences in maternal stress response during an in-scanner psychosocial stress challenge.
The second aim i s to assess whether childhood adversity is associated with differences in mother's interactions with their infants at 4 and 12 months of age. Finally, we will assess longitudinally the degree to which maternal disrupted communication leads to impairments in infant stress regulation, amygdala hypertrophy and altered functional connectivity at one year of age. A substudy will also evaluate the contribution of prenatal factors including acute and chronic stress hormone measures, maternal psychiatric symptomatology and partner conflict. Childhood adversity and disrupted parenting are the root preventable causes for a host of medical and psychiatric disorders including addiction that result in billions of dollars in health care expenditures. A detailed understanding of underlying mechanisms, critical time points, and mediating factors is necessary to design targeted interventions to preempt the adverse consequences of early adversity. The proposed program of research will provide data on potential early biomarkers for infant risk that are much more specific than broad maternal psychosocial factors and could lead to earlier and more effective identification of, and intervention in, risk-related developmental trajectories.

Public Health Relevance

Childhood adversity and disrupted parenting are the root preventable causes for a host of medical and psychiatric disorders that result in billions of dollars in health care expenditures. The proposed study will assess the role that maternal neurobiological differences associated with maternal childhood maltreatment play in shaping a mother's behavior toward her infant and her infant's responses to stressful situations. Identifying clinically-relevant neurobiological aspects of maternal behavior during infancy, when well- tailored interventions could have a dramatic preemptive effect on the child's long-term health outcomes, is of compelling national importance.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Project (R01)
Project #
5R01HD079484-05
Application #
9673750
Study Section
Psychosocial Development, Risk and Prevention Study Section (PDRP)
Program Officer
Griffin, James
Project Start
2015-04-10
Project End
2021-02-28
Budget Start
2019-03-01
Budget End
2021-02-28
Support Year
5
Fiscal Year
2019
Total Cost
Indirect Cost
Name
Mclean Hospital
Department
Type
DUNS #
046514535
City
Belmont
State
MA
Country
United States
Zip Code
02478
Teicher, Martin H; Anderson, Carl M; Ohashi, Kyoko et al. (2018) Differential effects of childhood neglect and abuse during sensitive exposure periods on male and female hippocampus. Neuroimage 169:443-452
Teicher, Martin H (2018) Childhood trauma and the enduring consequences of forcibly separating children from parents at the United States border. BMC Med 16:146
Ohashi, Kyoko; Anderson, Carl M; Bolger, Elizabeth A et al. (2018) Susceptibility or Resilience to Maltreatment Can Be Explained by Specific Differences in Brain Network Architecture. Biol Psychiatry :
Ohashi, Kyoko; Anderson, Carl M; Bolger, Elizabeth A et al. (2017) Childhood maltreatment is associated with alteration in global network fiber-tract architecture independent of history of depression and anxiety. Neuroimage 150:50-59
Granqvist, Pehr; Sroufe, L Alan; Dozier, Mary et al. (2017) Disorganized attachment in infancy: a review of the phenomenon and its implications for clinicians and policy-makers. Attach Hum Dev 19:534-558
Byun, Sooyeon; Brumariu, Laura E; Lyons-Ruth, Karlen (2016) Disorganized attachment in young adulthood as a partial mediator of relations between severity of childhood abuse and dissociation. J Trauma Dissociation 17:460-79
Lyons-Ruth, K; Pechtel, P; Yoon, S A et al. (2016) Disorganized attachment in infancy predicts greater amygdala volume in adulthood. Behav Brain Res 308:83-93
Teicher, Martin H; Samson, Jacqueline A (2016) Annual Research Review: Enduring neurobiological effects of childhood abuse and neglect. J Child Psychol Psychiatry 57:241-66