This Center for Excellence in Genomic Science will provide two major activities in genomics at the University of Pennsylvania. First, it will bring together investigators with a long-standing commitment to genetics, in a new inter-related set of research programs in the genomics of genetic variation. Second, the Center will make a substantial contribution to support of Genomics education at Penn, by providing graduate and postgraduate fellowship support. This project will address this phenomenon by systematically examining expression profiles on a genome-wide level, using microarray technology, and a relatively homogeneous collection of cell lines from the CEPH families. This project will identify sites showing polymorphism for presence/absence of integration by L1 mobile elements. These sites will then be related to the variation in gene expression level determined. This project will identify and characterize the polymorphic variation in chromosomal telomeric regions. These will also be mapped with relation to variation in expression level.

Agency
National Institute of Health (NIH)
Institute
National Human Genome Research Institute (NHGRI)
Type
Research Project (R01)
Project #
5R01HG002386-02
Application #
6526879
Study Section
Ethical, Legal, Social Implications Review Committee (GNOM)
Program Officer
Brooks, Lisa
Project Start
2001-09-30
Project End
2004-08-31
Budget Start
2002-09-01
Budget End
2003-08-31
Support Year
2
Fiscal Year
2002
Total Cost
$600,000
Indirect Cost
Name
University of Pennsylvania
Department
Genetics
Type
Schools of Medicine
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104