Abstract

Continuing the present study of the mechanism which balances the tissue need for oxygen with the production of red blood cells. The most appealing hypothesis involves the production and action of an erythropoietic hormone, the so-called erythropoietin. It is suggested that the oxygen tension in some specialized site, most likely the kidney, controls the production or release of this hormone. Following its release it is carried to the bone marrow where it controls the rate with which stem cells are differentiated into pronormoblasts. These pronormoblasts will divide and mature into adult red cells with the primary function of transporting oxygen to the tissues. This feedback circuit provides a simple regulating mechanism for red cell production. The proposed studies are designed to test each element in the chain which constitutes the effect of oxygen tension in the kidney.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL004612-28
Application #
3334182
Study Section
(EH)
Project Start
1974-09-01
Project End
1988-08-31
Budget Start
1986-09-01
Budget End
1988-08-31
Support Year
28
Fiscal Year
1986
Total Cost
Indirect Cost

  Institution

Name
Thomas Jefferson University
Department
Type
Schools of Medicine
DUNS #
061197161
City
Philadelphia
State
PA
Country
United States
Zip Code
19107

  Publications

Brassard, Jacqueline A; Curtis, Brian R; Cooper, Richard A et al. (2002) Acute thrombocytopenia in patients treated with the oral glycoprotein IIb/IIIa inhibitors xemilofiban and orbofiban: evidence for an immune etiology. Thromb Haemost 88:892-7
Flaharty, K K; Caro, J; Erslev, A et al. (1990) Pharmacokinetics and erythropoietic response to human recombinant erythropoietin in healthy men. Clin Pharmacol Ther 47:557-64
Erslev, A J; Caro, J; Schuster, S J (1989) Is there an optimal hemoglobin level? Transfus Med Rev 3:237-42
Piroso, E; Erslev, A J; Caro, J (1989) Inappropriate increase in erythropoietin titers during chemotherapy. Am J Hematol 32:248-54
Schuster, S J; Badiavas, E V; Costa-Giomi, P et al. (1989) Stimulation of erythropoietin gene transcription during hypoxia and cobalt exposure. Blood 73:13-6
Erslev, A J; Caro, J (1987) Erythropoietin titers in response to anemia or hypoxia. Blood Cells 13:207-16
Nielsen, O J; Schuster, S J; Kaufman, R et al. (1987) Regulation of erythropoietin production in a human hepatoblastoma cell line. Blood 70:1904-9
Schuster, S J; Wilson, J H; Erslev, A J et al. (1987) Physiologic regulation and tissue localization of renal erythropoietin messenger RNA. Blood 70:316-8
Schuster, S J; Caro, J; Erslev, A J (1987) Erythropoietin: current concepts and future prospects. Hematol Pathol 1:193-201
Erslev, A J; Caro, J; Besarab, A (1985) Why the kidney? Nephron 41:213-6

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