Abstract

Studies of internal iron kinetics in experimental animals and in man continue. The in vivo loading and unloading of transferrin iron as well as the molecular aspects of iron absorption are being examined. Other studies relate to the effects of tissue iron deficiency on body function. Iron overload is being studied in the families of patients with idiopathic hemochromatosis and in the general population. The relationship between myelopoiesis and bone formation is beng studied in experimental animals and in thalassemia.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL006242-25
Application #
3334194
Study Section
(SSS)
Project Start
1978-04-01
Project End
1987-03-31
Budget Start
1985-04-01
Budget End
1986-03-31
Support Year
25
Fiscal Year
1985
Total Cost
Indirect Cost

  Institution

Name
University of Washington
Department
Type
Schools of Medicine
DUNS #
135646524
City
Seattle
State
WA
Country
United States
Zip Code
98195

  Publications

Levine, D S; Huebers, H A; Rubin, C E et al. (1988) Blocking action of parenteral desferrioxamine on iron absorption in rodents and men. Gastroenterology 95:1242-8
Kim, B K; Huebers, H A; Finch, C A (1987) Effectiveness of oral iron chelators assayed in the rat. Am J Hematol 24:277-84
Kim, B K; Huebers, H; Pippard, M J et al. (1985) Storage iron exchange in the rat as affected by deferoxamine. J Lab Clin Med 105:440-8