Abstract

The purpose of the present proposal is to study the properties of the gas exchange system at the levels of the lung, blood and tissue. Gas phase mechanisms affecting pulmonary gas exchange will be studied by evaluating stratified inhomogeneity, density dependent inspired gas distribution and reinspiration of series dead space gas. Dynamic responses to local alterations in ventilation and perfusion will be studied using 81Krypton. The saturation dependent interaction of other ligands with carbon monoxide-hemoglobin binding will be studied in whole blood. The interrelationships between perfusion distribution, hemoglobin-oxygen affinity and oxygen delivery will be studied in skeletal muscle.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL012174-17
Application #
3334454
Study Section
Applied Physiology Study Section (AFY)
Project Start
1977-04-01
Project End
1985-11-30
Budget Start
1984-12-01
Budget End
1985-11-30
Support Year
17
Fiscal Year
1985
Total Cost
Indirect Cost

  Institution

Name
University of Washington
Department
Type
Schools of Medicine
DUNS #
135646524
City
Seattle
State
WA
Country
United States
Zip Code
98195

  Publications

Chang, Hung; Lai-Fook, Stephen J; Domino, Karen B et al. (2006) Redistribution of blood flow and lung volume between lungs in lateral decubitus postures during unilateral atelectasis and PEEP. Chin J Physiol 49:83-95
Chang, Hung; Lai-Fook, Stephen J; Domino, Karen B et al. (2006) Ventilation and perfusion distribution during altered PEEP in the left lung in the left lateral decubitus posture with unchanged tidal volume in dogs. Chin J Physiol 49:74-82
Robertson, H Thomas; Kreck, Thomas C; Krueger, Melissa A (2005) The spatial and temporal heterogeneity of regional ventilation: comparison of measurements by two high-resolution methods. Respir Physiol Neurobiol 148:85-95
Hubler, Matthias; Souders, Jennifer E; Shade, Erin D et al. (2002) Effects of perfluorohexane vapor on relative blood flow distribution in an animal model of surfactant-depleted lung injury. Crit Care Med 30:422-7
Chang, Hung; Lai-Fook, Stephen J; Domino, Karen B et al. (2002) Spatial distribution of ventilation and perfusion in anesthetized dogs in lateral postures. J Appl Physiol 92:745-62
Kreck, T C; Shade, E D; Lamm, W J et al. (2001) Isocapnic hyperventilation increases carbon monoxide elimination and oxygen delivery. Am J Respir Crit Care Med 163:458-62
Kreck, T C; Krueger, M A; Altemeier, W A et al. (2001) Determination of regional ventilation and perfusion in the lung using xenon and computed tomography. J Appl Physiol 91:1741-9
Lim, C M; Domino, K B; Glenny, R W et al. (2001) Effect of increasing perfluorocarbon dose on VA/Q distribution during partial liquid ventilation in acute lung injury. Anesthesiology 94:637-42
Hubler, M; Souders, J E; Shade, E D et al. (2001) Effects of vaporized perfluorocarbon on pulmonary blood flow and ventilation/perfusion distribution in a model of acute respiratory distress syndrome. Anesthesiology 95:1414-21
Brogan, T V; Hedges, R G; McKinney, S et al. (2000) Pulmonary NO synthase inhibition and inspired CO2: effects on V'/Q' and pulmonary blood flow distribution. Eur Respir J 16:288-95

Showing the most recent 10 out of 53 publications