The proposal has two specific aims: 1) to determine the extent to which baroreceptor denervation alters the renal response to volume expansion, head-out water immersion, and selective atrial distension in the primate. In addition, data will be obtained concerning the extent to which baroreceptor denervation may produce a hypertensive state, and 2) to determine if afferent neural activity from the kidney and liver can appraise the central nervous system of the composition and volume of blood which perfuses these organs. These proposals relate directly to understanding better salt and water homeostasis in man. Standard physiological methodology will be employed.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
2R01HL013427-14A2
Application #
3334649
Study Section
Cardiovascular and Pulmonary Research B Study Section (CVB)
Project Start
1985-09-30
Project End
1988-09-29
Budget Start
1985-09-30
Budget End
1986-09-29
Support Year
14
Fiscal Year
1985
Total Cost
Indirect Cost
Name
University of Nebraska Medical Center
Department
Type
Schools of Medicine
DUNS #
City
Omaha
State
NE
Country
United States
Zip Code
68198
Cornish, K G; Barazanji, M W; Yong, T et al. (1989) Volume expansion attenuates baroreflex sensitivity in the conscious nonhuman primate. Am J Physiol 257:R595-8
Gilmore, J P; Cornish, K G; Barazanji, M W (1988) Pentobarbital potentiates natriuretic response to acute volume expansion in monkeys. Am J Physiol 254:R727-9
Cornish, K G; Barazanji, M; Ryberg, A et al. (1988) Hypotension produced by vagal block in primates. Am J Physiol 254:R857-62
Wu, A P; Gilmore, J P (1987) Lack of evidence for a cerebral sodium modulating mechanism in the monkey. Basic Res Cardiol 82:319-25
Barazanji, M W; Cornish, K G (1987) Carotid and aortic baroreceptor control of heart rate in conscious monkey. Am J Physiol 253:H811-7
Horacek, M J; Earle, A M; Gilmore, J P (1985) An investigation of potential vascular connections between the kidney and the adrenal gland. Acta Anat (Basel) 123:9-13
Gilmore, J P; Tomomatsu, E (1985) Renal mechanoreceptors in nonhuman primates. Am J Physiol 248:R202-7
Wesley, C R; Gilmore, J P (1985) Effects of oxytocin, vasotocin and alpha-MSH on renal function in the nonhuman primate. Horm Res 21:55-9
Wang, S L; Gilmore, J P (1985) Renal responses to atrial natriuretic factor during converting enzyme inhibition. Can J Physiol Pharmacol 63:220-3