A series of controlled prospective clinical trials with supporting laboratory investigations in the pathophysiology of thrombotic states and related conditions and the pharmacology of new antithrombotic and hemostatic drugs will be conducted. The principal clinical trials, which are already in progress, include: (1) Study of a hemodynamically optimized system for external pneumatic compression of the lower limbs to prevent venous thrombosis in patients undergoing neurosurgical operations. (2) Investigation of the effectiveness and safety of therapy of established venous or arterial thromboembolism with a heparin preparation of low molecular weight and high antithrombin affinity. (3) Trial of the prevention of venous thromboembolism in patients with fractures of the hip by administration of a heparin-like compound (Organon 10172). (4) Administration of DDAVP to improve hemostasis in patients undergoing cardiopulmonary bypass and exploration of the role of von Willebrand's factor in the hemostatic defect in such patients.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL013754-18
Application #
3334695
Study Section
Surgery and Bioengineering Study Section (SB)
Project Start
1977-07-01
Project End
1989-08-31
Budget Start
1988-07-01
Budget End
1989-08-31
Support Year
18
Fiscal Year
1988
Total Cost
Indirect Cost
Name
Beth Israel Deaconess Medical Center
Department
Type
DUNS #
076593722
City
Boston
State
MA
Country
United States
Zip Code
02215
Salzman, E W; Weinstein, M J; Reilly, D et al. (1993) Adventures in hemostasis. Desmopressin in cardiac surgery. Arch Surg 128:212-7
Penny, W F; Weinstein, M; Salzman, E W et al. (1991) Correlation of circulating von Willebrand factor levels with cardiovascular hemodynamics. Circulation 83:1630-6
Gerhart, T N; Yett, H S; Robertson, L K et al. (1991) Low-molecular-weight heparinoid compared with warfarin for prophylaxis of deep-vein thrombosis in patients who are operated on for fracture of the hip. A prospective, randomized trial. J Bone Joint Surg Am 73:494-502
Weinstein, M; Ware, J A; Troll, J et al. (1988) Changes in von Willebrand factor during cardiac surgery: effect of desmopressin acetate. Blood 71:1648-55
Salzman, E W; McManama, G P; Shapiro, A H et al. (1987) Effect of optimization of hemodynamics on fibrinolytic activity and antithrombotic efficacy of external pneumatic calf compression. Ann Surg 206:636-41
Salzman, E W; Weinstein, M J; Weintraub, R M et al. (1986) Treatment with desmopressin acetate to reduce blood loss after cardiac surgery. A double-blind randomized trial. N Engl J Med 314:1402-6
Bertele, V; Stemerman, M; Schafer, A et al. (1985) Refractoriness of platelets to prostaglandins after infusion in rabbits. J Lab Clin Med 106:551-61
Lewis, J; Sweeney, J; Baldini, L et al. (1985) Assessment of thromboresistance of intravenous cannulae by 125I-fibrinogen scanning. J Biomed Mater Res 19:99-113