These studies are concerned with the isolation and characterization of the proteins associated with the cytoskeletal structure of human blood platelets. Two proteins, F-actin and actin-binding protein (ABP) have been isolated from platelets by a simplified procedure and when these are reassociated they form a structure resembling that which exists in the native platelet. Studies ar in progress to characterize the factors which may be involved in regulating the assembly-disassembly of the cytoskeleton of platelets.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL014020-12
Application #
3334716
Study Section
(EH)
Project Start
1978-12-01
Project End
1986-11-30
Budget Start
1984-12-01
Budget End
1985-11-30
Support Year
12
Fiscal Year
1985
Total Cost
Indirect Cost
Name
Suny Downstate Medical Center
Department
Type
Schools of Medicine
DUNS #
068552207
City
Brooklyn
State
NY
Country
United States
Zip Code
11203