The Program on Surgical Control of the Hyperlipidemias (POSCH) is a secondary (post a single myocardial infarction, unifactorial (hypertension, diabetes, and other major risk factors excluded) atherosclerosis-lipid intervention trial. The core facilities of POSCH (Central Lipid Laboratory, Central Electrocardiography Laboratory, Central Arteriography/ Radiology Laboratory, and the Office of Programs Administration) are located at the University of Minnesota; the four clinical centers of POSCH are at the University of Minnesota, University of Arkansas, University of Southern California, and the Lankenau Research Center, Philadelphia. The mode of intervention for POSCH is the partial ileal bypass operation. POSCH data have documented that this procedure causes a 25% reduction in total plasma cholesterol, a 40% LDL-cholesterol lowering, an 8% increase in the HDL-cholesterol, and an 80% increase in the HDL/LDL ratio. In addition to clinical endpoints, this trial provides sequential analyses of coronary arteriograms for at least five years after randomization for each participant. Recruitment and screening terminated in 1982-1983, and randomization terminated July 19, 1983 with 838 participating subjects. POSCH is currently in its follow-up phase. This application is for the completion of follow-up, termination of the trial, and analysis and publication of data. The results of this trial will answer the questiion of whether total plasma cholesterol reduction, or more precisely the lowering of the LDL-cholesterol and the raising of the HDL-cholesterol fractions, will affect the atherosclerosis process after a myocardial infarction.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL015265-17
Application #
3334911
Study Section
(SRC)
Project Start
1978-06-09
Project End
1992-05-31
Budget Start
1989-05-01
Budget End
1990-05-31
Support Year
17
Fiscal Year
1989
Total Cost
Indirect Cost
Name
University of Minnesota Twin Cities
Department
Type
Schools of Medicine
DUNS #
168559177
City
Minneapolis
State
MN
Country
United States
Zip Code
55455
Buchwald, Henry; Rudser, Kyle D; Williams, Stanley E et al. (2010) Overall mortality, incremental life expectancy, and cause of death at 25 years in the program on the surgical control of the hyperlipidemias. Ann Surg 251:1034-40
Buchwald, Henry; Williams, Stanley E; Matts, John P et al. (2002) Overall mortality in the program on the surgical control of the hyperlipidemias. J Am Coll Surg 195:327-31
Buchwald, Henry; Williams, Stanley E; Matts, John P et al. (2002) Lipid modulation and liver function tests. A report of the Program on the Surgical Control of the Hyperlipidemias (POSCH). J Cardiovasc Risk 9:83-7
Buchwald, H; Boen, J R; Nguyen, P A et al. (2001) Plasma lipids and cardiovascular risk: a POSCH report. Program on the Surgical Control of the Hyperlipidemias. Atherosclerosis 154:221-7
Buchwald, H; Varco, R L; Boen, J R et al. (1998) Effective lipid modification by partial ileal bypass reduced long-term coronary heart disease mortality and morbidity: five-year posttrial follow-up report from the POSCH. Program on the Surgical Control of the Hyperlipidemias. Arch Intern Med 158:1253-61
Buchwald, H; Hunter, D W; Tuna, N et al. (1998) Myocardial infarction and percent arteriographic stenosis of culprit lesion: report from the Program on the Surgical Control of the Hyperlipidemias (POSCH). Atherosclerosis 138:391-401
Buchwald, H; Campos, C T; Boen, J R et al. (1996) Gender-based mortality follow-up from the Program on the Surgical Control of the Hyperlipidemias (POSCH) and meta-analysis of lipid intervention trials. Women in POSCH and other lipid trials. Ann Surg 224:486-98;discussion 498-500
Buchwald, H; Bourdages, H R; Campos, C T et al. (1996) Impact of cholesterol reduction on peripheral arterial disease in the Program on the Surgical Control of the Hyperlipidemias (POSCH). Surgery 120:672-9
Fitch, L L; Buchwald, H; Matts, J P et al. (1995) Effect of aspirin use on death and recurrent myocardial infarction in current and former cigarette smokers. Program on the Surgical Control of the Hyperlipidemias Group. Am Heart J 129:656-62
Buchwald, H; Campos, C T (1995) Program on the surgical control of the hyperlipidemias: 1994 report. J Cardiovasc Pharmacol 25 Suppl 4:S3-10

Showing the most recent 10 out of 16 publications