This program is designed to provide a multidisciplined approach to the study of the physiological significance of in vitro blood rheology studies. The long range goal of the proposed research is to contribute to the understanding of the rheological properties of blood to: 1) the flow of blood in vivo; 2) the diagnosis and treatment of clinical disorders associated with potential rheologic alterations.
The specific aims of the present program include: 1) studies of the flow behavior of erythrocyte suspensions in geometries relevant to the microcirculation, including narrow bore glass tubes and portions of an in vitro flow replica derived from a microcirculatory bed; 2) continued physical-rheological analyses of the effects of storage of human blood intended for transfusion; 3) rheological studies of selected erythrocyte populations whose age, chemical-modification, metabolic state or shape make them relevant to the interests of the Research Program; 4) macro-and microrheological evaluation of blood from patients whose disease alters the rheology of blood and the use of selected hemorheological data as supporting information for patient care. Successful completion of the major aims of this program should provide; 1) quantitative information relevant to the prediction of pressure-flow-relations in a vascular bed based on in vitro rheologic data; 2) detailed data regarding the macro- and microrheological properties of stored and pathologic blood; 3) insight into the use of various rheological parameters as diagnostic and supportive information for patient care. Of long range significance is the potential contribution with studies of this type may make to clinical medicine; if syndromes of """"""""hyperviscosity"""""""" are to be utilized with scientific meaning, a clearer understanding of their etiology, rheologic mechanisms and physiological import is essential.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL015722-15
Application #
3335034
Study Section
Cardiovascular and Pulmonary Research B Study Section (CVB)
Project Start
1979-05-01
Project End
1989-04-30
Budget Start
1987-05-01
Budget End
1988-04-30
Support Year
15
Fiscal Year
1987
Total Cost
Indirect Cost
Name
University of Southern California
Department
Type
Schools of Medicine
DUNS #
041544081
City
Los Angeles
State
CA
Country
United States
Zip Code
90033
Alexy, Tamas; Pais, Eszter; Wenby, Rosalinda B et al. (2015) Abnormal blood rheology and chronic low grade inflammation: possible risk factors for accelerated atherosclerosis and coronary artery disease in Lewis negative subjects. Atherosclerosis 239:248-51
Sonmez, Melda; Ince, Huseyin Yavuz; Yalcin, Ozlem et al. (2013) The effect of alcohols on red blood cell mechanical properties and membrane fluidity depends on their molecular size. PLoS One 8:e76579
Meram, Ece; Yilmaz, Bahar D; Bas, Ceren et al. (2013) Shear stress-induced improvement of red blood cell deformability. Biorheology 50:165-76
Baskurt, Oguz K; Meiselman, Herbert J (2013) Red blood cell mechanical stability test. Clin Hemorheol Microcirc 55:55-62
Ulker, Pinar; Gunduz, Filiz; Meiselman, Herbert J et al. (2013) Nitric oxide generated by red blood cells following exposure to shear stress dilates isolated small mesenteric arteries under hypoxic conditions. Clin Hemorheol Microcirc 54:357-69
Rabai, Miklos; Meiselman, Herbert J; Wenby, Rosalinda B et al. (2012) Analysis of light scattering by red blood cells in ektacytometry using global pattern fitting. Biorheology 49:317-28
Ulker, Pinar; Yaras, Nazmi; Yalcin, Ozlem et al. (2011) Shear stress activation of nitric oxide synthase and increased nitric oxide levels in human red blood cells. Nitric Oxide 24:184-91
Alexy, Tamas; Baskurt, Oguz K; Nemeth, Norbert et al. (2011) Effect of lanthanides on red blood cell deformability and response to mechanical stress: role of lanthanide ionic radius. Biorheology 48:173-83
Gündüz, F; Koçer, G; Ulker, S et al. (2011) Exercise training enhances flow-mediated dilation in spontaneously hypertensive rats. Physiol Res 60:589-97
Uyuklu, Mehmet; Canpolat, Murat; Meiselman, Herbert J et al. (2011) Wavelength selection in measuring red blood cell aggregation based on light transmittance. J Biomed Opt 16:117006

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