Although much is known about the control of both cardiac output and pulmonary ventilation, the mechanisms which precisely match both responses to the metabolic demands of exercise remain incompletely understood. To obtain further insight into this question, this project is designed to study the degree of cardiopulmonary control coupling associated with an exogenous """"""""metabolic"""""""" gas load (i.e. appropriately matched CO2 addition and O2 removal) imposed on the systemic circulation of unanesthetized dogs. The question to be answered is whether or not such a load alone can provide the signal for its own normal homeostasis.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL016390-13
Application #
3335201
Study Section
Respiratory and Applied Physiology Study Section (RAP)
Project Start
1977-01-01
Project End
1987-12-31
Budget Start
1986-01-01
Budget End
1986-12-31
Support Year
13
Fiscal Year
1986
Total Cost
Indirect Cost
Name
University of Southern California
Department
Type
DUNS #
041544081
City
Los Angeles
State
CA
Country
United States
Zip Code
90033
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Chow, E; Cha, E J; Yamashiro, S M (1988) Ventilatory responses to increased blood flow and decreased lung volume in awake dogs. J Appl Physiol 65:714-20
Cha, E J; Chow, E; Chang, H K et al. (1988) Lung hyperinflation in isolated dog lungs during high-frequency oscillation. J Appl Physiol 65:1172-9
Hwang, W W; Yamashiro, S M; Sedlock, D et al. (1988) Ventilatory response to CO2 and O2 near eupnea in awake dogs. J Appl Physiol 65:788-96
Lin, C K; Levenson, H; Yamashiro, S M (1987) Optimization of coronary blood flow during cardiopulmonary resuscitation (CPR). IEEE Trans Biomed Eng 34:473-81
Ghazanshahi, S D; Yamashiro, S M; Marmarelis, V Z (1987) Use of a random forcing for high-frequency ventilation. J Appl Physiol 62:1201-5
Cha, E J; Sedlock, D; Yamashiro, S M (1987) Changes in lung volume and breathing pattern during exercise and CO2 inhalation in humans. J Appl Physiol 62:1544-50