Abstract

To determine the time course of coronary collateral development, instrumented dogs with coronary occlusions will be studied serially with thallium scanning. Following occlusion, the first scan is to be performed 2 days later with isotope injection during treadmill running. Following injection the animals will be anesthetized to permit scanning over a 4-hour period so that the reperfusion period can be observed. Then scans will be repeated every 5-7 days to measure the reduction in area of ischemia. Using the canine model of LAD occlusion and LCf stenosis, hemodynamics, distal LCf pressure, and myocardial blood flow will be examined following intracoronary Nifedipine injection. By evaluating the effect of the drug on distal LCf pressure and myocardial flow, the presence of steal will be determined.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL017809-12
Application #
3335452
Study Section
Respiratory and Applied Physiology Study Section (RAP)
Project Start
1978-07-01
Project End
1992-06-30
Budget Start
1989-07-01
Budget End
1990-06-30
Support Year
12
Fiscal Year
1989
Total Cost
Indirect Cost

  Institution

Name
Montefiore Medical Center (Bronx, NY)
Department
Type
DUNS #
City
New York
State
NY
Country
United States
Zip Code
10467

  Publications

Burckhartt, B; Yang, X M; Tsuchida, A et al. (1995) Acadesine extends the window of protection afforded by ischaemic preconditioning in conscious rabbits. Cardiovasc Res 29:653-7
Walsh, R S; Borges, M; Thornton, J D et al. (1995) Hypoxia preconditions rabbit myocardium by an adenosine receptor-mediated mechanism. Can J Cardiol 11:141-6
Downey, J M; Cohen, M V; Ytrehus, K et al. (1994) Cellular mechanisms in ischemic preconditioning: the role of adenosine and protein kinase C. Ann N Y Acad Sci 723:82-98
Cohen, M V; Yang, X M; Liu, Y et al. (1994) A new animal model of controlled coronary artery occlusion in conscious rabbits. Cardiovasc Res 28:61-5
Cohen, M V; Yang, X M; Downey, J M (1994) Conscious rabbits become tolerant to multiple episodes of ischemic preconditioning. Circ Res 74:998-1004
Ytrehus, K; Liu, Y; Tsuchida, A et al. (1994) Rat and rabbit heart infarction: effects of anesthesia, perfusate, risk zone, and method of infarct sizing. Am J Physiol 267:H2383-90
Cohen, M V; Vernon, J; Yaghdjian, V et al. (1994) Longitudinal changes in myocardial basic fibroblast growth factor (FGF-2) activity following coronary artery ligation in the dog. J Mol Cell Cardiol 26:683-90
Walsh, R S; Tsuchida, A; Daly, J J et al. (1994) Ketamine-xylazine anaesthesia permits a KATP channel antagonist to attenuate preconditioning in rabbit myocardium. Cardiovasc Res 28:1337-41
Cohen, M V (1993) Myocardial ischemia is not a prerequisite for the stimulation of coronary collateral development. Am Heart J 126:847-55
Cohen, M V; Chukwuogo, N; Yarlagadda, A (1993) Heparin does not stimulate coronary-collateral growth in a canine model of progressive coronary-artery narrowing and occlusion. Am J Med Sci 306:75-81

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