Abstract

The objective of this proposal is to determine the extent to which structural and/or functional changes take place in the microcirculation of renal, cardiac, cerebral and pulmonary tissue which is transplanted into the cheek pouch of hypertensive recipients. The Grollman and spontaneous hypertensive hamster models will be used. The structural measurements will include measurements of vessel wall thickness and vessel density. The functional measurements will include microvascular responsiveness to physiologic (PO2, PCO2, changes in transmural pressure) and pharmacologic (norepinephrine, angiotensin, K+) stimuli as well as measurement of vascular permeability and leakiness. This study should provide unique information regarding the microcirculatory changes that take place in hypertension as well as their cause.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL017902-14
Application #
3335479
Study Section
Experimental Cardiovascular Sciences Study Section (ECS)
Project Start
1977-04-01
Project End
1990-06-30
Budget Start
1988-04-01
Budget End
1989-06-30
Support Year
14
Fiscal Year
1988
Total Cost
Indirect Cost

  Institution

Name
University of Nebraska Medical Center
Department
Type
Schools of Medicine
DUNS #
City
Omaha
State
NE
Country
United States
Zip Code
68198

  Publications

Liese, Angela D; Nichols, Michele; Hodo, Denise et al. (2010) Food intake patterns associated with carotid artery atherosclerosis in the Insulin Resistance Atherosclerosis Study. Br J Nutr 103:1471-9
Liese, Angela D; Nichols, Michele; Sun, Xuezheng et al. (2009) Adherence to the DASH Diet is inversely associated with incidence of type 2 diabetes: the insulin resistance atherosclerosis study. Diabetes Care 32:1434-6
Beihl, Deborah A; Liese, Angela D; Haffner, Steven M (2009) Sleep duration as a risk factor for incident type 2 diabetes in a multiethnic cohort. Ann Epidemiol 19:351-7
Liese, Angela D; Weis, Kristina E; Schulz, Mandy et al. (2009) Food intake patterns associated with incident type 2 diabetes: the Insulin Resistance Atherosclerosis Study. Diabetes Care 32:263-8
Liese, Angela D; Gilliard, Theodosha; Schulz, Mandy et al. (2007) Carbohydrate nutrition, glycaemic load, and plasma lipids: the Insulin Resistance Atherosclerosis Study. Eur Heart J 28:80-7
Schulz, Mandy; Liese, Angela D; Fang, Fang et al. (2006) Is the association between dietary glycemic index and type 2 diabetes modified by waist circumference? Diabetes Care 29:1102-4
Schulz, Mandy; Liese, Angela D; Mayer-Davis, Elizabeth J et al. (2005) Nutritional correlates of dietary glycaemic index: new aspects from a population perspective. Br J Nutr 94:397-406
Liese, Angela D; Schulz, Mandy; Fang, Fang et al. (2005) Dietary glycemic index and glycemic load, carbohydrate and fiber intake, and measures of insulin sensitivity, secretion, and adiposity in the Insulin Resistance Atherosclerosis Study. Diabetes Care 28:2832-8
Liese, Angela D; Schulz, Mandy; Moore, Charity G et al. (2004) Dietary patterns, insulin sensitivity and adiposity in the multi-ethnic Insulin Resistance Atherosclerosis Study population. Br J Nutr 92:973-84
Liese, Angela D; Roach, Amy K; Sparks, Karen C et al. (2003) Whole-grain intake and insulin sensitivity: the Insulin Resistance Atherosclerosis Study. Am J Clin Nutr 78:965-71

Showing the most recent 10 out of 21 publications