Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL018912-12
Application #
3335693
Study Section
Cardiovascular and Pulmonary Research A Study Section (CVA)
Project Start
1976-04-01
Project End
1993-04-30
Budget Start
1991-05-01
Budget End
1993-04-30
Support Year
12
Fiscal Year
1991
Total Cost
Indirect Cost
Name
Johns Hopkins University
Department
Type
Schools of Medicine
DUNS #
045911138
City
Baltimore
State
MD
Country
United States
Zip Code
21218
Snyder, D S; Harasawa, Y; Sagawa, K et al. (1993) Effects of pentobarbital on inotropic state of isolated canine left ventricle. Heart Vessels 8:128-35
Burkhoff, D; De Tombe, P P; Hunter, W C (1993) Impact of ejection on magnitude and time course of ventricular pressure-generating capacity. Am J Physiol 265:H899-909
De Tombe, P P; Jones, S; Burkhoff, D et al. (1993) Ventricular stroke work and efficiency both remain nearly optimal despite altered vascular loading. Am J Physiol 264:H1817-24
Harasawa, Y; de Tombe, P P; Sheriff, D D et al. (1992) Basal metabolism adds a significant offset to unloaded myocardial oxygen consumption per minute. Circ Res 71:414-22
de Tombe, P P; Burkhoff, D; Hunter, W C (1992) Effects of calcium and EMD-53998 on oxygen consumption in isolated canine hearts. Circulation 86:1945-54
de Tombe, P P; Burkhoff, D; Hunter, W C (1992) Comparison between the effects of 2-3 butanedione monoxime (BDM) and calcium chloride on myocardial oxygen consumption. J Mol Cell Cardiol 24:783-97
Wolff, M R; de Tombe, P P; Harasawa, Y et al. (1992) Alterations in left ventricular mechanics, energetics, and contractile reserve in experimental heart failure. Circ Res 70:516-29
Sugiura, S; Hunter, W C; Waclawiw, M A et al. (1991) Dynamic properties of left ventricular response to changes in coronary perfusion. Am J Physiol 260:H1332-43
Burkhoff, D; de Tombe, P P; Hunter, W C et al. (1991) Contractile strength and mechanical efficiency of left ventricle are enhanced by physiological afterload. Am J Physiol 260:H569-78
Schipke, J D; Burkhoff, D; Kass, D A et al. (1990) Hemodynamic dependence of myocardial oxygen consumption indexes. Am J Physiol 258:H1281-91

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