Abstract

Vasopressin (antidiuretic hormone, ADH) plays a major role in the regulation of blood volume, which in turn is a key, if not the predominant, factor in the long-term regulation of blood pressure. In the past several years, it has been demonstrated that the secretion of ADH from neurohypophysis is elevated in several forms of experimental and clinical hypertension. Furthermore, in some types of hypertension, ADH appears to function as a pressor agent in the maintenance of the elevated blood pressure. We propose to study the following in several different models of experimental hypertension: the effect of the orally effective converting enzyme inhibitor, SQ14, 225, on ADH secretion, and where it does have an effect, its mechanism action; the role of prostaglandins in the increased ADH secretion; pressor and renal sensitivity to ADH; and the handling of ADH by the isolated perfused rat kidney. ADH and PGE2 will be measured by radioimmunoassay.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL019209-10
Application #
3335763
Study Section
Cardiovascular and Pulmonary Research B Study Section (CVB)
Project Start
1976-06-01
Project End
1987-06-30
Budget Start
1985-07-01
Budget End
1986-06-30
Support Year
10
Fiscal Year
1985
Total Cost
Indirect Cost

  Institution

Name
University of Tennessee Health Science Center
Department
Type
Schools of Medicine
DUNS #
941884009
City
Memphis
State
TN
Country
United States
Zip Code
38163

  Publications

He, X R; Wang, W; Crofton, J T et al. (1999) Effects of 17beta-estradiol on the baroreflex control of sympathetic activity in conscious ovariectomized rats. Am J Physiol 277:R493-8
He, X R; Wang, W; Crofton, J T et al. (1998) Effects of 17beta-estradiol on sympathetic activity and pressor response to phenylephrine in ovariectomized rats. Am J Physiol 275:R1202-8
Crofton, J T; Share, L (1997) Gonadal hormones modulate deoxycorticosterone-salt hypertension in male and female rats. Hypertension 29:494-9
Wang, Y X; Crofton, J T; Share, L (1997) Sex differences in the cardiovascular and renal actions of vasopressin in conscious rats. Am J Physiol 272:R370-6
Wang, Y X; Crofton, J T; Bealer, S L et al. (1997) Sexual dimorphism in regional blood flow responses to vasopressin in conscious rats. Am J Physiol 273:R1126-31
Wang, Y X; Crofton, J T; Liu, H et al. (1996) V2-receptor blockade enhances pressor response to vasopressin: gender difference. Life Sci 59:695-703
Wang, Y X; Crofton, J T; Miller, J et al. (1996) Sex difference in urinary concentrating ability of rats with water deprivation. Am J Physiol 270:R550-5
Liu, H W; Wang, Y X; Crofton, J T et al. (1996) Central vasopressin blockade enhances its peripheral release in response to peripheral osmotic stimulation in conscious rats. Brain Res 719:14-22
Wang, Y X; Crofton, J T; Liu, H et al. (1995) Estradiol attenuates the antidiuretic action of vasopressin in ovariectomized rats. Am J Physiol 268:R951-7
Sato, K; Crofton, J T; Wang, Y X et al. (1995) Effects of gender on the central actions of neuropeptide Y and norepinephrine on vasopressin and blood pressure in the rat. Brain Res 689:71-8

Showing the most recent 10 out of 59 publications