Abstract

The overall goal is to describe the respiratory-related efferent activities of the hypoglossal and trigeminal nerves. These activities and those of muscles which they innervate in the oropharyngeal region have been shown to be important for maintaining upper airway patency, especially in sleep. Alterations in these neural or muscular activities or those of single hypoglossal and trigeminal neurons will be characterized in response to changes in chemoreceptor stimuli or elicitation of upper airway and/or pulmonary reflexes. Changes in these activities will also be analyzed following administration of pharmacological substances which differentially alter activities of the hypoglossal and trigeminal systems as compared to the bulbospinalphrenic system. It is hypothesized that these differential actions reflect a greater dependency for activites of hypoglossal and trigeminal neurons than bulbospinal neurons upon reticular formation processes. Data obtained will provide significant insights into mechanisms required for maintenance of upper airway patency. These data may have direct and immediate applications to the diagnosis and treatment of obstructive apneas in adults and children.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL020574-11
Application #
3336161
Study Section
Respiratory and Applied Physiology Study Section (RAP)
Project Start
1977-09-01
Project End
1989-08-31
Budget Start
1986-09-01
Budget End
1987-08-31
Support Year
11
Fiscal Year
1986
Total Cost
Indirect Cost

  Institution

Name
Dartmouth College
Department
Type
Schools of Medicine
DUNS #
041027822
City
Hanover
State
NH
Country
United States
Zip Code
03755

  Publications

Zhou, D; Huang, Q; Fung, M L et al. (1996) Phrenic response to hypercapnia in the unanesthetized, decerbrate, newborn rat. Respir Physiol 104:11-22
St John, W M (1996) Medullary regions for neurogenesis of gasping: noeud vital or noeuds vitals? J Appl Physiol 81:1865-77
Coates, E L; Knuth, S L; Bartlett Jr, D (1996) Laryngeal CO2 receptors: influence of systemic PCO2 and carbonic anhydrase inhibition. Respir Physiol 104:53-61
Hwang, J C; St John, W M (1993) Facilitation and inhibition of phrenic motoneuronal activities by lung inflation. J Appl Physiol 74:2485-92
Fregosi, R F; Hwang, J C; Bartlett Jr, D et al. (1992) Activity of abdominal muscle motoneurons during hypercapnia. Respir Physiol 89:179-94
St John, W M; Zhou, D (1992) Reductions of neural activities to upper airway muscles after elevations in static lung volume. J Appl Physiol 73:701-7
Fregosi, R F; Bartlett Jr, D; St John, W M (1990) Influence of phasic volume feedback on abdominal expiratory nerve activity. Respir Physiol 82:189-200
St John, W M (1990) Neurogenesis, control, and functional significance of gasping. J Appl Physiol 68:1305-15
Huang, Q; Zhou, D; St John, W M et al. (1989) Influence of lung volume on activities of branches of the recurrent laryngeal nerve. J Appl Physiol 67:1179-84
Zhou, D; St John, W M; Bartlett Jr, D (1989) Activities of pulmonary stretch receptors during ventilatory cycles without lung inflation. Respir Physiol 77:187-94

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