Abstract

We propose to continue studies defining the electrical fields generated by chronic and transient myocardial ischemia. Four projects are defined. First, the equivalent generator properties of the isolated canine heart will be determined before and after coronary ligation. Efforts will be focused on determining the physiologic relevance of dipole ranging methods in assessing the location and extent of ischemic lesions. Second, isopotential mapping and dipole ranging techniques will be applied to surface recordings from intact dogs before and after coronary occlusion to extend the results from isolated hearts to intact animal models. Third, human subjects with acute myocardial infarction will be investigated to determine the patterns of ST-T abnormalities in relation to lead system design, equivalent generator properties and electrogenesis of standard ECG abnormalities. Last, surface mapping during supine exercise will continue in an effort to define the relation between coronary pathoanatomy and distribution of ECG changes, to evaluate lead system design, and to determine diagnostic criteria in subjects with abnormal resting electrocardiograms.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL020597-08
Application #
3336173
Study Section
Cardiovascular and Pulmonary Research B Study Section (CVB)
Project Start
1977-07-01
Project End
1986-03-31
Budget Start
1985-04-01
Budget End
1986-03-31
Support Year
8
Fiscal Year
1985
Total Cost
Indirect Cost

  Institution

Name
University of Tennessee Health Science Center
Department
Type
Schools of Medicine
DUNS #
941884009
City
Memphis
State
TN
Country
United States
Zip Code
38163

  Publications

Halle 3rd, A A; Mirvis, D M; Sullivan, J M et al. (1989) Dose effects of adenine on myocardial ATP content in the post-anoxic nonworking rat heart. Gen Pharmacol 20:817-20
Ramanathan, K B; Wilson, J L; Mirvis, D M (1988) Effects of coronary occlusion on transmural distribution of blood flow in the interventricular septum and left ventricular free wall. Basic Res Cardiol 83:229-37
Mirvis, D M (1988) Physiologic bases for anterior ST segment depression in patients with acute inferior wall myocardial infarction. Am Heart J 116:1308-22
Mirvis, D M; Ramanathan, K B; Wilson, J L (1988) Comparative electrocardiographic and myocardial blood flow effects of rapid atrial pacing and dipyridamole infusion in dogs with chronic coronary artery occlusion. Am Heart J 115:984-92
Wilson, J L; Ramanathan, K B; Ingram, L A et al. (1988) Effects of residual stenosis on infarct size and regional transmural myocardial blood flow after reperfusion. Am Heart J 116:1523-9
Nichols, T L; Lawson, M A; Mirvis, D M (1987) Determination of cardiac equivalent generator properties using a numerical expansion method. J Electrocardiol 20:352-6
Mirvis, D M; Ramanathan, K B (1987) Alterations in transmural blood flow and body surface ST segment abnormalities produced by ischemia in the circumflex and left anterior descending coronary arterial beds of the dog. Circulation 76:697-704
Mirvis, D M (1987) Current status of body surface electrocardiographic mapping. Circulation 75:684-8
Mirvis, D M (1987) Detection of experimental right ventricular infarction by isopotential body surface mapping during sinus rhythm and during ectopic ventricular pacing. J Am Coll Cardiol 10:157-63
Mirvis, D M; Ramanathan, K B; Wilson, J L (1986) Regional blood flow correlates of ST segment depression in tachycardia-induced myocardial ischemia. Circulation 73:365-73

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