It is well recognized that atherosclerosis is a major medical problem which involves major arteries supplying the heart, the brain and the extremities. It has been possible with the development of ultrasonic techniques to evaluate the location and extent of the involvement in the carotid and peripheral arteries. Since the method is noninvasive, painless and safe, it has been possible to utilize the combination of pulse echo and Doppler methods to assess the degree of narrowing at the time of the examination and to follow changes in the disease during follow-up. It is proposed to further develop these methods to employ the use of computerized pattern recognition which will permit quantification of information present in the Doppler spectrum to predict the degree of stenosis. In addition to providing a more objective assessment of the degree of stenosis, the ultrasonic duplex method will be used to assess the prevalence of restenosis after carotid endarterectomy and its relevance to the development of clinical events such as transient ischemic attacks and strokes.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL020898-11
Application #
3336306
Study Section
Surgery and Bioengineering Study Section (SB)
Project Start
1986-09-08
Project End
1991-08-31
Budget Start
1988-09-08
Budget End
1989-08-31
Support Year
11
Fiscal Year
1988
Total Cost
Indirect Cost
Name
University of Washington
Department
Type
Schools of Medicine
DUNS #
135646524
City
Seattle
State
WA
Country
United States
Zip Code
98195
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Phillips, D J; Hossack, J; Beach, K W et al. (1990) Testing ultrasonic pulsed Doppler instruments with a physiologic string phantom. J Ultrasound Med 9:429-36
Phillips, D J (1990) Recent advances in carotid artery evaluation. Clin Diagn Ultrasound 26:25-44
Hatsukami, T S; Healy, D A; Primozich, J F et al. (1990) Fate of the carotid artery contralateral to endarterectomy. J Vasc Surg 11:244-50;discussion 250-1
Kohler, T R; Andros, G; Porter, J M et al. (1990) Can duplex scanning replace arteriography for lower extremity arterial disease? Ann Vasc Surg 4:280-7

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