Abstract

The broad objective of our work is to understand the neural regulation of cardiac conduction and excitation. The specific objectives of this proposal are to study the dynamic interaction of transient and stea state vagal and sympathetic stimulation on dromotropic and inotropic cardiac responses, and the dynamic three-way interaction of heart period and activity of both autonomic divisions on these responses. We shall also study the influence of atrial fibrillation on the autonomic control of AV conduction. In particular, the autonomic influence on the compensatory pause, and on the ventricular rate, and the contribution of the baroreflex to ventricular function will be studied with atrial fibrillation. Finally, we shall study the time dependencies of cardiac responses to brief bursts and continuous trains of vagal stimuli, and provide data relative to the possible mechanisms of these primary and secondary transient effects.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL022484-08
Application #
3336892
Study Section
Cardiovascular Study Section (CVA)
Project Start
1978-07-01
Project End
1986-06-30
Budget Start
1985-07-01
Budget End
1986-06-30
Support Year
8
Fiscal Year
1985
Total Cost
Indirect Cost

  Institution

Name
Mount Sinai Medical Center
Department
Type
DUNS #
City
Cleveland
State
OH
Country
United States
Zip Code
44106

  Publications

Hill, M R; Wallick, D W; Mongeon, L R et al. (1995) Vasoactive intestinal polypeptide antagonists attenuate vagally induced tachycardia in the anesthetized dog. Am J Physiol 269:H1467-72
Kuguoglu, A F; Wallick, D W; Martin, P J (1995) Facilitated ventriculoatrial conduction: effects of sequential pacing interval and basic cycle length. Am J Physiol 268:H384-90
Hill, M R; Wallick, D W; Martin, P J et al. (1995) Effects of repetitive vagal stimulation on heart rate and on cardiac vasoactive intestinal polypeptide efflux. Am J Physiol 268:H1939-46
Carlson, M D; White, R D; Trohman, R G et al. (1994) Right ventricular outflow tract ventricular tachycardia: detection of previously unrecognized anatomic abnormalities using cine magnetic resonance imaging. J Am Coll Cardiol 24:720-7
Hill, M R; Wallick, D W; Martin, P J et al. (1993) Frequency dependence of vasoactive intestinal polypeptide release and vagally induced tachycardia in the canine heart. J Auton Nerv Syst 43:117-22
Wallick, D W; Xu, R G; Martin, P J (1992) Dynamic interaction of vagal activity and heart rate on atrioventricular conduction. Am J Physiol 262:H792-8
Carlson, M D; Geha, A S; Hsu, J et al. (1992) Selective stimulation of parasympathetic nerve fibers to the human sinoatrial node. Circulation 85:1311-7
Yang, T N; Cheng, J; Martin, P et al. (1991) Effects of spatial dispersion of acetylcholine release on AV conduction responses to vagal stimulation in dogs. Am J Physiol 261:H392-7
Wallick, D W; Martin, P J (1990) Separate parasympathetic control of heart rate and atrioventricular conduction of dogs. Am J Physiol 259:H536-42
Furukawa, Y; Wallick, D W; Martin, P J et al. (1990) Chronotropic and dromotropic responses to stimulation of intracardiac sympathetic nerves to sinoatrial or atrioventricular nodal region in anesthetized dogs. Circ Res 66:1391-9

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