Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL022533-12
Application #
2215580
Study Section
Bio-Organic and Natural Products Chemistry Study Section (BNP)
Project Start
1979-04-01
Project End
1996-11-30
Budget Start
1994-12-01
Budget End
1996-11-30
Support Year
12
Fiscal Year
1995
Total Cost
Indirect Cost

  Institution

Name
University of Tennessee Health Science Center
Department
Pharmacology
Type
Schools of Pharmacy
DUNS #
941884009
City
Memphis
State
TN
Country
United States
Zip Code
38163

  Publications

Nikulin, Victor I; Rakov, Igor M; De Los Angeles, Joseph E et al. (2006) 1-Benzyl-1,2,3,4-tetrahydroisoquinoline-6,7-diols as novel affinity and photoaffinity probes for beta-adrenoceptor subtypes. Bioorg Med Chem 14:1684-97
Konkar, A A; Nikulin, V I; De Los Angeles , J et al. (2001) Biochemical activities of trimetoquinol analogs at human beta(1)- and beta(3)-adrenergic receptors. Pharmacology 62:45-55
Mehta, R C; Salazar-Bookaman, M M; Fertel, R H et al. (2000) Biochemical and functional characterization of 1-benzyl substituted trimetoquinol affinity analogs on rat and human beta-adrenoceptors. Biochem Pharmacol 59:517-29
Zheng, W; Nikulin, V I; Konkar, A A et al. (1999) 2-Amino-4-benzyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridines: novel selective beta3-adrenoceptor agonists. J Med Chem 42:2287-94
Konkar, A A; Vansal, S S; Shams, G et al. (1999) Beta-adrenoceptor subtype activities of trimetoquinol derivatives: biochemical studies on human beta-adrenoceptors expressed in chinese hamster ovary cells. J Pharmacol Exp Ther 291:875-83
Christoff, J J; Bradley, L; Miller, D D et al. (1997) Synthesis and evaluation of trimetoquinol derivatives: novel thromboxane A2/prostaglandin H2 antagonists with diminished beta-adrenergic agonist activity. J Med Chem 40:85-91
Shams, G; Romstedt, K J; Lust, L A et al. (1997) Beta-adrenergic receptor and platelet inhibitory activities of a new series of trimetoquinol and related benzazepine analogs. Gen Pharmacol 28:323-30
Romstedt, K J; Lei, L P; Feller, D R et al. (1996) Differential eudismic ratios in the antagonism of human platelet function by phenoxy- and thiophenoxyacetic acids. Farmaco 51:107-14
Konkar, A A; Fraundorfer, P F; Fertel, R H et al. (1996) Pharmacological activities of trimetoquinol and 1-benzyl halogen-substituted analogues on rat beta-adrenoceptor subtypes. Eur J Pharmacol 305:63-71
De Los Angeles, J E; Nikulin, V I; Shams, G et al. (1996) Iodinated analogs of trimetoquinol as highly potent and selective beta 2-adrenoceptor ligands. J Med Chem 39:3701-11

Showing the most recent 10 out of 32 publications