This study of 2500 persons in 50 extended pedigrees will elucidate the mechanisms by which genetic and environmental factors interact to control blood pressure and lead to hypertension. Utah investigators will conduct a clinical screening study of 2500 subjects in 50 pedigrees of 4-5 generations, most of them ascertained with the help of the population-based computer file of Utah pedigrees (currently containing over 1,000,000 persons). Data collection will include detailed questionnaires of lifestyle and habits; height, weight, skinfold thickness; multiple blood pressure measurement before and after special stress tests; multiple 12-hour urine samples for sodium, potassium, creatinine, kallikrein and prostaglandins; and blood samples for creatinine, sodium, potassium, uric acid, cholesterol, renin, hematocrit, and fasting glucose. These detailed data collected from subjects in 50 large pedigrees will be analyzed to elucidate the etiological factors for blood pressure and hypertension including: mechanisms of genetic transmission (few major genes vs. Galtonian polygenic gene frequencies, number of alleles and loci, degree of dominance); the role of environmental factor (such as sodium and calorie intake, stress, etc.) which interact with genes or affect their penetrance; and the degree of heterogeneity between pedigrees. These data will be collected at the beginning of the study and again at the end of the study in order to document, over time, those factors which may contribute significantly to elevated blood pressure.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL024855-06
Application #
3337842
Study Section
Epidemiology and Disease Control Subcommittee 3 (EDC)
Project Start
1980-02-01
Project End
1986-01-31
Budget Start
1985-02-01
Budget End
1986-01-31
Support Year
6
Fiscal Year
1985
Total Cost
Indirect Cost
Name
University of Utah
Department
Type
Schools of Medicine
DUNS #
City
Salt Lake City
State
UT
Country
United States
Zip Code
84112
Shirts, Brian H; Howard, Michael T; Hasstedt, Sandra J et al. (2012) Vitamin D dependent effects of APOA5 polymorphisms on HDL cholesterol. Atherosclerosis 222:167-74
Shirts, Brian H; Hasstedt, Sandra J; Hopkins, Paul N et al. (2011) Evaluation of the gene-age interactions in HDL cholesterol, LDL cholesterol, and triglyceride levels: the impact of the SORT1 polymorphism on LDL cholesterol levels is age dependent. Atherosclerosis 217:139-41
Büsst, Cara J; Bloomer, Lisa D S; Scurrah, Katrina J et al. (2011) The epithelial sodium channel ?-subunit gene and blood pressure: family based association, renal gene expression, and physiological analyses. Hypertension 58:1073-8
Hasstedt, Sandra J; Xin, Yuanpei; Hopkins, Paul N et al. (2010) Two-dimensional, sex-specific autosomal linkage scan of the number of sodium pump sites. J Hypertens 28:740-7
Hunt, Steven C; Xin, Yuanpei; Wu, Lily L et al. (2006) Sodium bicarbonate cotransporter polymorphisms are associated with baseline and 10-year follow-up blood pressures. Hypertension 47:532-6
Johnson, Jenny; Giles, Rebecca T; Larsen, Ladene et al. (2005) Utah's Family High Risk Program: bridging the gap between genomics and public health. Prev Chronic Dis 2:A24
Coon, Hilary; Xin, Yuanpei; Hopkins, Paul N et al. (2005) Upstream stimulatory factor 1 associated with familial combined hyperlipidemia, LDL cholesterol, and triglycerides. Hum Genet 117:444-51
Hasstedt, Sandra J; Camp, Nicola J; Hopkins, Paul N et al. (2004) Model-fitting and linkage analysis of sodium-lithium countertransport. Eur J Hum Genet 12:1055-61
Hunt, Steven C; Coon, Hilary; Hasstedt, Sandra J et al. (2004) Linkage of serum creatinine and glomerular filtration rate to chromosome 2 in Utah pedigrees. Am J Hypertens 17:511-5
Camp, Nicola J; Hopkins, Paul N; Hasstedt, Sandra J et al. (2003) Genome-wide multipoint parametric linkage analysis of pulse pressure in large, extended utah pedigrees. Hypertension 42:322-8

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