Abstract

Significant advances have been made in understanding the Cardiovascular system. However, little attention has been given to the myocardial microcirculation. We propose to study the regulatory mechanisms of coronary microvascular flow and transport in health and in diabetes mellitus. We will use intravital microscopy assisted by computer image analysis to visualize the epimyocardial microcirculation. Morphometric analysis will be performed also by light, scanning and electron microscopy to determine structure-function relationships. The indicator dilution method will be used to assess the overall transport capacity of the heart. Diabetes mellitus will be chemically induced. The coronary microvascular alterations in flow and transport will be investigated. Our results will provide a basis to further understand the adaptive mechanisms by which the coronary microcirculation meets myocardial metabolic demands and how these control processes are altered by diabetes mellitus.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL025032-06
Application #
3337947
Study Section
Cardiovascular and Pulmonary Research B Study Section (CVB)
Project Start
1981-07-01
Project End
1988-06-30
Budget Start
1986-07-01
Budget End
1988-06-30
Support Year
6
Fiscal Year
1986
Total Cost
Indirect Cost

  Institution

Name
University of Medicine & Dentistry of NJ
Department
Type
Schools of Medicine
DUNS #
605799469
City
Newark
State
NJ
Country
United States
Zip Code
07107

  Publications

Hall, J E; Guyton, A C; Brands, M W (1996) Pressure-volume regulation in hypertension. Kidney Int Suppl 55:S35-41
Blebea, J; Cambria, R A; DeFouw, D et al. (1990) Iloprost attenuates the increased permeability in skeletal muscle after ischemia and reperfusion. J Vasc Surg 12:657-65;discussion 665-6
Kim, D; Armenante, P M; Duran, W N (1990) Mathematical modeling of mass transfer in microvascular wall and interstitial space. Microvasc Res 40:358-78
Breitbart, G B; Dillon, P K; Suval, W D et al. (1990) Leukopenia reduces microvascular clearance of macromolecules in ischemia-reperfusion injury. Curr Surg 47:8-12
Paul, J; Bekker, A Y; Duran, W N (1990) Calcium entry blockade prevents leakage of macromolecules induced by ischemia-reperfusion in skeletal muscle. Circ Res 66:1636-42
Paul, J; Duran, W N (1989) Concentration dependent effects of calcium blockade on vessel diameter and microvascular macromolecular clearance. Microcirc Endothelium Lymphatics 5:441-55
Bekker, A Y; Ritter, A B; Duran, W N (1989) Analysis of microvascular permeability to macromolecules by video-image digital processing. Microvasc Res 38:200-16
Breitbart, G B; Dillon, P K; Suval, W D et al. (1989) Dexamethasone attenuates microvascular ischemia-reperfusion injury in the rat cremaster muscle. Microvasc Res 38:155-63
Duran, W N; Dillon, P K (1989) Effects of ischemia-reperfusion injury on microvascular permeability in skeletal muscle. Microcirc Endothelium Lymphatics 5:223-39
Bekker, A Y; Dillon, P K; Paul, J et al. (1988) Dose-response relationships between platelet activating factor and permeability--surface area product of FITC-dextran 150 in the hamster cheek pouch. Microcirc Endothelium Lymphatics 4:433-46

Showing the most recent 10 out of 19 publications