The object of this project is to bring to a successful close the total synthesis of the alkaloid Germine, the parent compound of a number of esters which are known to possess hypotensive activity. Germine has been selected not only because of its biological interest, but because it presents a major synthetic challenge in part as a result of its sixteen asymmetric centers. The overall strategy involves the coupling of a segment representing rings A- B-C and half of D with one having the makings of the other half of ring D together with rings E and F.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL025635-11
Application #
3338165
Study Section
Medicinal Chemistry Study Section (MCHA)
Project Start
1980-04-01
Project End
1992-03-31
Budget Start
1990-04-01
Budget End
1991-03-31
Support Year
11
Fiscal Year
1990
Total Cost
Indirect Cost
Name
Columbia University (N.Y.)
Department
Type
Other Domestic Higher Education
DUNS #
064931884
City
New York
State
NY
Country
United States
Zip Code
10027