The overall objective of our research on skeletal muscle blood flow is identification of the mechanisms responsible for vasodilation associated with exercise. The major focus of this application is the role of endothelial cells in mediating the vasodilation of distributing arteries which are responsible for maintaining the pressure head to the microcirculation during exercise. We are also interested in the role of endothelial cells in the dilation and development of collateral vessels which supply the microcirculation when distributing arteries are occluded. We propose to elucidate the physiologic importance of endothelial cells in mediating the vasodilation of distributing arteries. Our goals are (a) to determine the physiologic role of distributing artery flow-dependent dilation in exercise hyperemia, (b) to further characterize the mechanism of flow-dependent dilation in the canine femoral artery, and (c) to determine the role of endothelial cells in the dilation and growth of collateral vessels during acute and chronic occlusion of the distributing artery. We will also examine the effect of heartworm (Dirofilaria immitis), a common filarial parasitic infection of domestic dogs, on endothelium-dependent vasodilation.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL025779-12
Application #
3338249
Study Section
Experimental Cardiovascular Sciences Study Section (ECS)
Project Start
1980-04-01
Project End
1993-03-31
Budget Start
1991-04-01
Budget End
1992-03-31
Support Year
12
Fiscal Year
1991
Total Cost
Indirect Cost
Name
Michigan State University
Department
Type
Schools of Medicine
DUNS #
193247145
City
East Lansing
State
MI
Country
United States
Zip Code
48824
Kaiser, L; Lamb, V L; Tithof, P K et al. (1992) Dirofilaria immitis: do filarial cyclooxygenase products depress endothelium-dependent relaxation in the in vitro rat aorta? Exp Parasitol 75:159-67
Kaiser, L; Ptu, S (1992) Effects of increasing age on vascular responses of the in vivo femoral artery of adult beagles. Gerontology 38:121-6
Kaiser, L; Tithof, P K; Lamb, V L et al. (1991) Depression of endothelium-dependent relaxation in aorta from rats with Brugia pahangi lymphatic filariasis. Circ Res 68:1703-12
Kaiser, L; Tithof, P K; Williams, J F (1990) Depression of endothelium-dependent relaxation by filarial parasite products. Am J Physiol 259:H648-52
Kaiser, L; Spickard, R C; Sparks Jr, H V et al. (1989) Dirofilaria immitis: alteration of endothelium-dependent relaxation in the in vivo canine femoral artery. Exp Parasitol 69:9-15
Kaiser, L; Spickard, R C; Olivier, N B (1989) Heart failure depresses endothelium-dependent responses in canine femoral artery. Am J Physiol 256:H962-7
Gorman, M W; Barclay, J K; Sparks, H V (1988) Effects of ischemia on VO2, tension, and vascular resistance in contracting canine skeletal muscle. J Appl Physiol 65:1075-81
Kaiser, L; Williams, J F; Meade, E A et al. (1987) Altered endothelial cell-mediated arterial dilation in dogs with D. immitis infection. Am J Physiol 253:H1325-9
Kaiser, L; Sparks Jr, H V (1987) Effect of hemodilution on endothelium-dependent vasodilation in the in vivo canine femoral artery. Circ Shock 23:107-18
Kaiser, L; Sparks Jr, H V (1987) Endothelial cells. Not just a cellophane wrapper. Arch Intern Med 147:569-73

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