Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL025820-14
Application #
2215886
Study Section
Toxicology Subcommittee 2 (TOX)
Project Start
1981-06-01
Project End
1997-08-31
Budget Start
1995-09-01
Budget End
1997-08-31
Support Year
14
Fiscal Year
1995
Total Cost
Indirect Cost
Name
Louisiana State University A&M Col Baton Rouge
Department
Type
Other Domestic Higher Education
DUNS #
075050765
City
Baton Rouge
State
LA
Country
United States
Zip Code
70803
Stone, K; Bermudez, E; Zang, L Y et al. (1995) The ESR properties, DNA nicking, and DNA association of aged solutions of catechol versus aqueous extracts of tar from cigarette smoke. Arch Biochem Biophys 319:196-203
Stone, K K; Bermudez, E; Pryor, W A (1994) Aqueous extracts of cigarette tar containing the tar free radical cause DNA nicks in mammalian cells. Environ Health Perspect 102 Suppl 10:173-8
Evans, M D; Pryor, W A (1994) Cigarette smoking, emphysema, and damage to alpha 1-proteinase inhibitor. Am J Physiol 266:L593-611
Bermudez, E; Stone, K; Carter, K M et al. (1994) Environmental tobacco smoke is just as damaging to DNA as mainstream smoke. Environ Health Perspect 102:870-4
Winston, G W; Church, D F; Cueto, R et al. (1993) Oxygen consumption and oxyradical production from microsomal reduction of aqueous extracts of cigarette tar. Arch Biochem Biophys 304:371-8
Evans, M D; Pryor, W A (1992) Damage to human alpha-1-proteinase inhibitor by aqueous cigarette tar extracts and the formation of methionine sulfoxide. Chem Res Toxicol 5:654-60
Nakayama, T; Church, D F; Pryor, W A (1989) Quantitative analysis of the hydrogen peroxide formed in aqueous cigarette tar extracts. Free Radic Biol Med 7:9-15
Lachocki, T M; Church, D F; Pryor, W A (1988) Persistent free radicals in the smoke of common household materials: biological and clinical implications. Environ Res 45:127-39
Borish, E T; Pryor, W A; Venugopal, S et al. (1987) DNA synthesis is blocked by cigarette tar-induced DNA single-strand breaks. Carcinogenesis 8:1517-20
Pryor, W A; Dooley, M M; Church, D F (1986) The inactivation of alpha-1-proteinase inhibitor by gas-phase cigarette smoke: protection by antioxidants and reducing species. Chem Biol Interact 57:271-83

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