This is a proposal to ascertain the mortality of the 361,622 men aged 35-57 who were seen at the initial screening of the Multiple Risk Factor Intervention Trial (MRFIT) through 10 years of follow-up. Using the location of death supplied by the Social Security Administration (SSA), state departments of health will be contacted to obtain death certificates. Currently 5 year all cause and cause-specific mortality data are available. By the end of the current grant period mortality data through 6 years will be available for all men. This proposal, which represents a continuation of the current grant, will employ methods established in the current grant and will permit more definitive analyses to be performed on two major research questions: 1) the associations of cause specific cancer mortality and serum cholesterol concentration, and 2) the association of serum cholesterol, diastolic blood pressure and cigarettes per day with mortality from coronary heart disease, and cerebrovascular disease for black and white men. For the first question, this group represents the largest prospective cohort study yet analyzed. The additional data will allow comparisons of the association of serum cholesterol and cancer mortality to be made for different cancer sites. In addition to the cholesterol-cancer question and the comparison of black and white men in the association of major risk factors with cardiovascular endpoints, further investigations on the development of risk prediction equations, and on methodological issues associated with using SSA data files and the National Death Index will be carried out.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL028715-05
Application #
3340022
Study Section
Epidemiology and Disease Control Subcommittee 3 (EDC)
Project Start
1982-04-01
Project End
1987-07-31
Budget Start
1986-08-01
Budget End
1987-07-31
Support Year
5
Fiscal Year
1986
Total Cost
Indirect Cost
Name
University of Minnesota Twin Cities
Department
Type
Schools of Public Health
DUNS #
168559177
City
Minneapolis
State
MN
Country
United States
Zip Code
55455
Stamler, J; Stamler, R; Neaton, J D et al. (1999) Low risk-factor profile and long-term cardiovascular and noncardiovascular mortality and life expectancy: findings for 5 large cohorts of young adult and middle-aged men and women. JAMA 282:2012-8
Vaccaro, O; Stamler, J; Neaton, J D (1998) Sixteen-year coronary mortality in black and white men with diabetes screened for the Multiple Risk Factor Intervention Trial (MRFIT). Int J Epidemiol 27:636-41
Davey Smith, G; Neaton, J D; Wentworth, D et al. (1998) Mortality differences between black and white men in the USA: contribution of income and other risk factors among men screened for the MRFIT. MRFIT Research Group. Multiple Risk Factor Intervention Trial. Lancet 351:934-9
Neaton, J D; Wentworth, D N (1997) Low serum cholesterol and risk of death from AIDS. AIDS 11:929-30
Brancati, F L; Whelton, P K; Randall, B L et al. (1997) Risk of end-stage renal disease in diabetes mellitus: a prospective cohort study of men screened for MRFIT. Multiple Risk Factor Intervention Trial. JAMA 278:2069-74
Klag, M J; Whelton, P K; Randall, B L et al. (1997) End-stage renal disease in African-American and white men. 16-year MRFIT findings. JAMA 277:1293-8
Coughlin, S S; Neaton, J D; Randall, B et al. (1997) Predictors of mortality from kidney cancer in 332,547 men screened for the Multiple Risk Factor Intervention Trial. Cancer 79:2171-7
Smith, G D; Wentworth, D; Neaton, J D et al. (1996) Socioeconomic differentials in mortality risk among men screened for the Multiple Risk Factor Intervention Trial: II. Black men. Am J Public Health 86:497-504
Smith, G D; Neaton, J D; Wentworth, D et al. (1996) Socioeconomic differentials in mortality risk among men screened for the Multiple Risk Factor Intervention Trial: I. White men. Am J Public Health 86:486-96
Coughlin, S S; Neaton, J D; Sengupta, A (1996) Cigarette smoking as a predictor of death from prostate cancer in 348,874 men screened for the Multiple Risk Factor Intervention Trial. Am J Epidemiol 143:1002-6

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