The purpose of this proposal is to investigate means to identify and inform couples who may wish to utilize prenatal diagnosis for sickle cell anemia or for Beta-thalassemia before the birth of their first affected child. Specifically, we intend to provide testing and genetic counseling for sickle trait and for Beta-thalassemia trait to pregnant women and, as a result: 1. To determine the frequency with which women identified as carriers during pregnancy refer their mates for carrier testing. 2. To compare two videotapes especially designed for trait counseling during pregnancy for effectiveness in inducing mate referral. 3. To identify factors predictive of mate referral which may be useful for increasing the effectiveness of future screening programs.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL029231-03
Application #
3340341
Study Section
Behavioral Medicine Study Section (BEM)
Project Start
1983-01-01
Project End
1985-12-31
Budget Start
1985-01-01
Budget End
1985-12-31
Support Year
3
Fiscal Year
1985
Total Cost
Indirect Cost
Name
University of Rochester
Department
Type
Schools of Medicine
DUNS #
208469486
City
Rochester
State
NY
Country
United States
Zip Code
14627
Rowley, P T; Loader, S; Sutera, C J et al. (1995) Prenatal genetic counseling for hemoglobinopathy carriers: a comparison of primary providers of prenatal care and professional genetic counselors. Am J Hum Genet 56:769-76
Loader, S; Sutera, C J; Walden, M et al. (1991) Prenatal screening for hemoglobinopathies. II. Evaluation of counseling. Am J Hum Genet 48:447-51
Rowley, P T; Loader, S; Sutera, C J et al. (1991) Prenatal screening for hemoglobinopathies. III. Applicability of the health belief model. Am J Hum Genet 48:452-9
Loader, S; Sutera, C J; Segelman, S G et al. (1991) Prenatal hemoglobinopathy screening. IV. Follow-up of women at risk for a child with a clinically significant hemoglobinopathy. Am J Hum Genet 49:1292-9
Rowley, P T; Loader, S; Sutera, C J et al. (1991) Prenatal screening for hemoglobinopathies. I. A prospective regional trial. Am J Hum Genet 48:439-46
Rowley, P T (1990) Newborn screening for hemoglobinopathies. Semin Perinatol 14:483-7
Rowley, P T (1989) Parental receptivity to neonatal sickle trait identification. Pediatrics 83:891-3
Rowley, P T (1989) Prenatal diagnosis for sickle cell disease. A survey of the United States and Canada. Ann N Y Acad Sci 565:48-52
Rowley, P T; Loader, S O; Sutera, C J et al. (1987) Prenatal hemoglobinopathy screening: receptivity of Southeast Asian refugees. Am J Prev Med 3:317-22
Joishy, S K; Shafer, J A; Rowley, P T (1986) The contribution of red cell morphology to the diagnosis of beta-thalassemia trait. Blood Cells 11:367-74