Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL029293-14
Application #
2216424
Study Section
Lung Biology and Pathology Study Section (LBPA)
Project Start
1982-09-01
Project End
1997-08-31
Budget Start
1995-09-01
Budget End
1997-08-31
Support Year
14
Fiscal Year
1995
Total Cost
Indirect Cost
Name
Wake Forest University Health Sciences
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
041418799
City
Winston-Salem
State
NC
Country
United States
Zip Code
27106
Mueller, L P; Yoza, B K; Neuhaus, K et al. (2001) Endotoxin-adapted septic shock leukocytes selectively alter production of sIL-1RA and IL-1beta. Shock 16:430-7
Yoza, B K; Hu, J Y; Cousart, S L et al. (2000) Endotoxin inducible transcription is repressed in endotoxin tolerant cells. Shock 13:236-43
Learn, C A; Mizel, S B; McCall, C E (2000) mRNA and protein stability regulate the differential expression of pro- and anti-inflammatory genes in endotoxin-tolerant THP-1 cells. J Biol Chem 275:12185-93
Delong, P; O'Sullivan, M G; Huggins, E et al. (1999) Bacterial lipopolysaccharide induction of the prostaglandin G/H synthase 2 gene causes thromboxane-dependent pulmonary hypertension in rabbits. Am J Respir Cell Mol Biol 20:493-9
Yoza, B; LaRue, K; McCall, C (1998) Molecular mechanisms responsible for endotoxin tolerance. Prog Clin Biol Res 397:209-15
Yoza, B K; Wells, J D; McCall, C E (1998) Interleukin-1beta expression after inhibition of protein phosphatases in endotoxin-tolerant cells. Clin Diagn Lab Immunol 5:281-7
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Yoza, B K; Hu, J Y; McCall, C E (1996) Protein-tyrosine kinase activation is required for lipopolysaccharide induction of interleukin 1beta and NFkappaB activation, but not NFkappaB nuclear translocation. J Biol Chem 271:18306-9
McCall, C E; Grosso-Wilmoth, L M; LaRue, K et al. (1993) Tolerance to endotoxin-induced expression of the interleukin-1 beta gene in blood neutrophils of humans with the sepsis syndrome. J Clin Invest 91:853-61
O'Sullivan, M G; Huggins Jr, E M; McCall, C E (1993) Lipopolysaccharide-induced expression of prostaglandin H synthase-2 in alveolar macrophages is inhibited by dexamethasone but not by aspirin. Biochem Biophys Res Commun 191:1294-300

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