Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL029939-12
Application #
2216542
Study Section
Physiological Chemistry Study Section (PC)
Project Start
1983-07-01
Project End
1997-03-31
Budget Start
1995-07-01
Budget End
1997-03-31
Support Year
12
Fiscal Year
1995
Total Cost
Indirect Cost
Name
University of Illinois Urbana-Champaign
Department
Biochemistry
Type
Schools of Arts and Sciences
DUNS #
041544081
City
Champaign
State
IL
Country
United States
Zip Code
61820
Kosman, J; Jonas, A (2001) Deletion of specific glycan chains affects differentially the stability, local structures, and activity of lecithin-cholesterol acyltransferase. J Biol Chem 276:37230-6
Cho, K H; Durbin, D M; Jonas, A (2001) Role of individual amino acids of apolipoprotein A-I in the activation of lecithin:cholesterol acyltransferase and in HDL rearrangements. J Lipid Res 42:379-89
Jonas, A (2000) Lecithin cholesterol acyltransferase. Biochim Biophys Acta 1529:245-56
Cho, K H; Jonas, A (2000) A key point mutation (V156E) affects the structure and functions of human apolipoprotein A-I. J Biol Chem 275:26821-7
Jin, L; Shieh, J J; Grabbe, E et al. (1999) Surface plasmon resonance biosensor studies of human wild-type and mutant lecithin cholesterol acyltransferase interactions with lipoproteins. Biochemistry 38:15659-65
Kosek, A B; Durbin, D; Jonas, A (1999) Binding affinity and reactivity of lecithin cholesterol acyltransferase with native lipoproteins. Biochem Biophys Res Commun 258:548-51
Adimoolam, S; Jin, L; Grabbe, E et al. (1998) Structural and functional properties of two mutants of lecithin-cholesterol acyltransferase (T123I and N228K). J Biol Chem 273:32561-7
Adimoolam, S; Lee, Y P; Jonas, A (1998) Mutagenesis of highly conserved histidines in lecithincholesterol acyltransferase: identification of an essential histidine (His 377). Biochem Biophys Res Commun 243:337-41
Jonas, A (1998) Regulation of lecithin cholesterol acyltransferase activity. Prog Lipid Res 37:209-34
Lee, Y P; Adimoolam, S; Liu, M et al. (1997) Analysis of human lecithin-cholesterol acyltransferase activity by carboxyl-terminal truncation. Biochim Biophys Acta 1344:250-61

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