The research is focused around the use of four different model systems that will be used to assess the potential of the laser for the reduction and/or removal of atheromas from blood vessels. The goals are to examine the mechanisms of laser interaction with atheromas as well as to define the optimal set of laser, fiber optic, and control (imaging) parameters. These studies will assess these parameters in an atherosclerotic rabbit model (acute study); in an in vitro human arterial segment perfusion system where vasoreactivity can be monitored physiologically; in a human atherosclerotic arterial segment that has been grafted into the coronary system of the pig and treated under fluoroscopic guidance; and in an atherosclerotic pig model where the thrombogenicity of the laser treatment sites can be assayed by Indium-111 radiographic imaging. These four model systems will be used to evaluate the laser for both laser endarterectomy and laser angioplasty. These methods will also be combined with histologic analysis. Finally, extensive mutagenesis and carcinogenesis testing will be performed on the ultraviolet laser wavelengths that show promise for non-thermal photoablative removal of plaque.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL031318-06
Application #
3342420
Study Section
Diagnostic Radiology Study Section (RNM)
Project Start
1983-12-01
Project End
1989-11-30
Budget Start
1988-12-01
Budget End
1989-11-30
Support Year
6
Fiscal Year
1989
Total Cost
Indirect Cost
Name
University of California Irvine
Department
Type
Schools of Medicine
DUNS #
161202122
City
Irvine
State
CA
Country
United States
Zip Code
92697
Baribeau, Y; Eugene, J; Nhu, T T et al. (1991) Excimer laser radiation for endarterectomy of experimental atheromas. J Invest Surg 4:247-58
Eugene, J; Ott, R A; Nudelman, K L et al. (1990) Initial clinical evaluation of carotid artery laser endarterectomy. J Vasc Surg 12:499-503
Eugene, J; Ott, R A; Baribeau, Y et al. (1990) Initial trial of argon ion laser endarterectomy for peripheral vascular disease. Arch Surg 125:1007-10;discussion 1010-1
Baribeau, Y; Eugene, J; Firestein, S L et al. (1990) Comparison of contact and free beam laser endarterectomy. J Surg Res 48:127-33
Berns, M W; Wright, W H; Tromberg, B J et al. (1989) Use of a laser-induced optical force trap to study chromosome movement on the mitotic spindle. Proc Natl Acad Sci U S A 86:4539-43
Tobis, J; Smolin, M; Mallery, J et al. (1989) Laser-assisted thermal angioplasty in human peripheral artery occlusions: mechanism of recanalization. J Am Coll Cardiol 13:1547-54
Rasmussen, R E; Hammer-Wilson, M; Berns, M W (1989) Mutation and sister chromatid exchange induction in Chinese hamster ovary (CHO) cells by pulsed excimer laser radiation at 193 nm and 308 nm and continuous UV radiation at 254 nm. Photochem Photobiol 49:413-8
Morcos, N C; Berns, M; Henry, W L (1988) Effect of laser-heated tip angioplasty on human atherosclerotic coronary arteries. Lasers Surg Med 8:22-9
Morcos, N C; Berns, M; Henry, W L (1988) Phycocyanin: laser activation, cytotoxic effects, and uptake in human atherosclerotic plaque. Lasers Surg Med 8:10-7
Eugene, J; Pollock, M E; McColgan, S J et al. (1987) Comparison of continuous-wave lasers for endarterectomy of experimental atheromas. J Thorac Cardiovasc Surg 93:494-501

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