The long term goals of this research are to identify in blacks for comparison with whites, the predictors or coronary disease morbidity and disability; and to assess the role that these various domains of functional status plays in mortality from coronary disease and all causes. We will also assess the extent of familial aggregation of risk factors between Charleston Heart Study cohort members and their progeny and identify correlates and potential causes of obesity, particularly in black women. The familial aggregation studies will examine risk factors using measured data collected from both parent and offspring as adults. Changes in risk factor status over generations will also be examined in blacks and whites. The obesity study will focus on the effects of race on body image and attitudes associated with restrained eating. The attainment of these goals will have an immediate influence on public health practices for blacks and whites. The methods for this research employ a classical disease, functional disability, and mortality. The Charleston Heart Study cohort (n=2287) provide baseline and followup risk factor measurements for assessment of subsequent disease, functional disability and mortality. Data from the Evans County, Georgia Heart Study will be compared to that from the CHS and the two data sets will be combined, if appropriate, to provide enhanced statistical power. In addition, a sample of the offspring of the original Charleston Heart Study cohort members will be recruited (n-2200) for the studies of familial aggregation and obesity.

National Institute of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
Research Project (R01)
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Epidemiology and Disease Control Subcommittee 2 (EDC)
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Medical University of South Carolina
Internal Medicine/Medicine
Schools of Medicine
United States
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Lackland, D T; Keil, J E (1996) Epidemiology of hypertension in African Americans. Semin Nephrol 16:63-70
Keil, J E; Sutherland, S E; Hames, C G et al. (1995) Coronary disease mortality and risk factors in black and white men. Results from the combined Charleston, SC, and Evans County, Georgia, heart studies. Arch Intern Med 155:1521-7
Lackland, D T; Keil, J E; Gazes, P C et al. (1995) Outcomes of black and white hypertensive individuals after 30 years of follow-up. Clin Exp Hypertens 17:1091-105
Hames, C G; Rose, K; Knowles, M et al. (1993) Black-white comparisons of 20-year coronary heart disease mortality in the Evans County Heart Study. Cardiology 82:122-36
Keil, J E; Sutherland, S E; Knapp, R G et al. (1993) Mortality rates and risk factors for coronary disease in black as compared with white men and women. N Engl J Med 329:73-8
Knapp, R G; Schreiner, P J; Sutherland, S E et al. (1993) Serum lipoprotein(a) levels in elderly black and white men in the Charleston Heart Study. Clin Genet 44:225-31
Sutherland, S E; Gazes, P C; Keil, J E et al. (1993) Electrocardiographic abnormalities and 30-year mortality among white and black men of the Charleston Heart Study. Circulation 88:2685-92
Keil, J E; Sutherland, S E; Knapp, R G et al. (1992) Skin color and mortality. Am J Epidemiol 136:1295-302
Knapp, R G; Sutherland, S E; Keil, J E et al. (1992) A comparison of the effects of cholesterol on CHD mortality in black and white women: twenty-eight years of follow-up in the Charleston Heart Study. J Clin Epidemiol 45:1119-29
Keil, J E; Sutherland, S E; Knapp, R G et al. (1992) Does equal socioeconomic status in black and white men mean equal risk of mortality? Am J Public Health 82:1133-6

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