The research proposed here investigates the physiologic mechanisms which are important in maintaining oxygen transport at high altitudes. The project is designed to identify both the genetically based adaptive mechanisms which may be present in species native to high altitude and the phenotypic acclimatization responses which may be present in lowland species, but only expressed following exposure to conditions of ambient hypoxia. The specific objective of the proposed research is to determine the relationship between ambient hypoxia and tissue capillarity. The hypothesis to be tested is that there are changes at the tissue level to potentiate oxygen diffusion from the blood to the sites of oxidative metabolism; namely, a reduction in the diffusion distance via an increased tissue capillarity. We further propose that the adaptive response is primarily, or entirely, seen in the embryo. The research proposed here will provide baseline information on tissue capillarity and the importance of increases in tissue capillarity in maintaining tissue oxygenation during exposure to ambient hypoxia.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL032894-02
Application #
3344421
Study Section
Human Embryology and Development Subcommittee 2 (HED)
Project Start
1984-09-01
Project End
1987-08-31
Budget Start
1985-09-01
Budget End
1986-08-31
Support Year
2
Fiscal Year
1985
Total Cost
Indirect Cost
Name
University of Colorado at Boulder
Department
Type
Schools of Arts and Sciences
DUNS #
City
Boulder
State
CO
Country
United States
Zip Code
80309
Snyder, G K; Baudinette, R V; Gannon, B J (1999) Oxygen transport and acid-base balance during exercise in the tammar wallaby. Respir Physiol 117:41-51
Snyder, G K; Nestler, J R; Shapiro, J I et al. (1995) Intracellular pH in lizards after hypercapnia. Am J Physiol 268:R889-95
Snyder, G K; Sheafor, B; Scholnick, D et al. (1995) Gas exchange in the insect tracheal system. J Theor Biol 172:199-207
Snyder, G K (1995) Capillary growth in chick skeletal muscle with normal maturation and hypertrophy. Respir Physiol 102:293-301
Scholnick, D A; Snyder, G K; Spell, A R (1994) Acid-base status of a pulmonate land snail (Helix aspersa) and a prosobranch amphibious snail (Pomacea bridgesi) during dormancy. J Exp Zool 268:293-8
Farrelly, C A; Snyder, G K (1993) An improved method for studying microvascular geometry using fluorescent dyes: preventing dye extravasation, preserving dye integrity and enhancing tissue morphometry. Biotech Histochem 68:106-12
Snyder, G K; Farrelly, C; Coelho, J R (1992) Capillary perfusion in skeletal muscle. Am J Physiol 262:H828-32
Snyder, G K; Farrelly, C; Coelho, J R (1992) Adaptations in skeletal muscle capillarity following changes in oxygen supply and changes in oxygen demands. Eur J Appl Physiol Occup Physiol 65:158-63
Nestler, J R (1992) Tissue-specific metabolism during normothermy and daily torpor in deer mice (Peromyscus maniculatus). J Exp Zool 261:406-13
Baudinette, R V; Snyder, G K; Frappell, P B (1992) Energetic cost of locomotion in the tammar wallaby. Am J Physiol 262:R771-8

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