The proposed study is a longitudinal investigation of social, dietary, and anthropometric predictors of changes in blood pressure in a large, economically diverse southern, Black population. Study participants (665 men, 1,119 women) were between 25-50 years of age in 1988, the year of the baseline survey, and resided in Pitt County, NC. This community is part of a region in the southeastern U.S. known to have elevated mortality from coronary heart disease and stroke. Efforts will be made to re-interview the 1,429 respondents (571 men, 912 women) with untreated, mean diastolic blood pressure < 95 mmHg at baseline, and again at follow-up, on changes in blood pressure during the intervening 4-5 years (1988-1992/93) will be examined. The social variables include socioeconomic status (SES), John Henryism, stress, and social support; the dietary variables include alcohol, sodium, potassium, and calcium; and the anthropometric variables include body mass index (BMI) and waist/hip ratio (WHR). With an emphasis on SES, physical activity, dietary habits, and cigarette smoking, the predictors of weight gain, and changes in patterning of body fat will also be examined. Multiple linear regression will be the primary analytic tool used to study these longitudinal relationships. In cross-sectional analyses which control for physical activity and other important variables, the role of insulin resistance in mediating associations between obesity and blood pressure, and stress and blood pressure, will also be examined. Thus this study aims to clarify interrelationships among social, behavioral, and biological determinants of hypertension in Black Americans. Study findings will be used to plan clinical and public health interventions in this and other similarly high risk Black populations.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
2R01HL033211-06
Application #
3344824
Study Section
Epidemiology and Disease Control Subcommittee 2 (EDC)
Project Start
1984-12-01
Project End
1996-04-30
Budget Start
1992-05-15
Budget End
1993-04-30
Support Year
6
Fiscal Year
1992
Total Cost
Indirect Cost
Name
University of Michigan Ann Arbor
Department
Type
Schools of Public Health
DUNS #
791277940
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109
Curtis, A B; Strogatz, D S; James, S A et al. (1998) The contribution of baseline weight and weight gain to blood pressure change in African Americans: the Pitt County Study. Ann Epidemiol 8:497-503
James, S A; Jamjoum, L; Raghunathan, T E et al. (1998) Physical activity and NIDDM in African-Americans. The Pitt County Study. Diabetes Care 21:555-62
Curtis, A B; James, S A; Raghunathan, T E et al. (1997) Job strain and blood pressure in African Americans: the Pitt County Study. Am J Public Health 87:1297-302
Strogatz, D S; Croft, J B; James, S A et al. (1997) Social support, stress, and blood pressure in black adults. Epidemiology 8:482-7
James, S A (1994) John Henryism and the health of African-Americans. Cult Med Psychiatry 18:163-82
Croft, J B; Strogatz, D S; Keenan, N L et al. (1993) The independent effects of obesity and body fat distribution on blood pressure in black adults: the Pitt County study. Int J Obes Relat Metab Disord 17:391-7
James, S A; Keenan, N L; Strogatz, D S et al. (1992) Socioeconomic status, John Henryism, and blood pressure in black adults. The Pitt County Study. Am J Epidemiol 135:59-67
Keenan, N L; Strogatz, D S; James, S A et al. (1992) Distribution and correlates of waist-to-hip ratio in black adults: the Pitt County Study. Am J Epidemiol 135:678-84
Croft, J B; Strogatz, D S; James, S A et al. (1992) Socioeconomic and behavioral correlates of body mass index in black adults: the Pitt County Study. Am J Public Health 82:821-6
Ainsworth, B E; Keenan, N L; Strogatz, D S et al. (1991) Physical activity and hypertension in black adults: the Pitt County Study. Am J Public Health 81:1477-9

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