Abstract

This research project focuses on the development of a clinically useful small diameter vascular graft. Such a graft could be applied as implants for lower extremity arterial reconstruction, coronary artery bypass, carotid prostheses, pediatric vessel repair and blood access. In order to accomplish this goal, we propose to investigate different glow discharge (RFGD) treatments to Dacron, expanded PTFE and polyurethane grafts, the resultant changes in graft surface composition and wettability, and the effects of these processes and properties on the in vivo biological interactions which lead to improved graft performance.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL033229-03
Application #
3344861
Study Section
Surgery and Bioengineering Study Section (SB)
Project Start
1985-01-01
Project End
1988-12-31
Budget Start
1987-01-01
Budget End
1987-12-31
Support Year
3
Fiscal Year
1987
Total Cost
Indirect Cost

  Institution

Name
University of Washington
Department
Type
Schools of Medicine
DUNS #
135646524
City
Seattle
State
WA
Country
United States
Zip Code
98195

  Publications

Kiaei, D; Hoffman, A S; Horbett, T A et al. (1995) Platelet and monoclonal antibody binding to fibrinogen adsorbed on glow-discharge-deposited polymers. J Biomed Mater Res 29:729-39
Pettit, D K; Hoffman, A S; Horbett, T A (1994) Correlation between corneal epithelial cell outgrowth and monoclonal antibody binding to the cell binding domain of adsorbed fibronectin. J Biomed Mater Res 28:685-91
Kiaei, D; Hoffman, A S; Horbett, T A (1992) Tight binding of albumin to glow discharge treated polymers. J Biomater Sci Polym Ed 4:35-44
Pettit, D K; Horbett, T A; Hoffman, A S (1992) Influence of the substrate binding characteristics of fibronectin on corneal epithelial cell outgrowth. Student Research Award in the Doctoral Degree Candidate Category, Fourth World Biomaterials Congress (18th annual meeting of the Society for Biomateria J Biomed Mater Res 26:1259-75
Kiaei, D; Hoffman, A S; Hanson, S R (1992) Ex vivo and in vitro platelet adhesion on RFGD deposited polymers. J Biomed Mater Res 26:357-72
Pettit, D K; Horbett, T A; Hoffman, A S et al. (1990) Quantitation of rabbit corneal epithelial cell outgrowth on polymeric substrates in vitro. Invest Ophthalmol Vis Sci 31:2269-77
Bohnert, J L; Fowler, B C; Horbett, T A et al. (1990) Plasma gas discharge deposited fluorocarbon polymers exhibit reduced elutability of adsorbed albumin and fibrinogen. J Biomater Sci Polym Ed 1:279-97
Hoffman, A S (1987) Modification of material surfaces to affect how they interact with blood. Ann N Y Acad Sci 516:96-101
Clowes, A W; Zacharias, R K; Kirkman, T R (1987) Early endothelial coverage of synthetic arterial grafts: porosity revisited. Am J Surg 153:501-4
Zacharias, R K; Kirkman, T R; Clowes, A W (1987) Mechanisms of healing in synthetic grafts. J Vasc Surg 6:429-36