Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL033593-02
Application #
3345625
Study Section
Cardiovascular Study Section (CVA)
Project Start
1984-12-01
Project End
1989-11-30
Budget Start
1985-12-01
Budget End
1986-11-30
Support Year
2
Fiscal Year
1986
Total Cost
Indirect Cost
Name
University of Pennsylvania
Department
Type
Schools of Veterinary Medicine
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Spear, J F; Hook, B G; Josephson, M E et al. (1997) Modulation of procainamide's effect on conduction by cellular uncoupling in perfused rabbit hearts. J Cardiovasc Electrophysiol 8:199-214
Callans, D J; Moore, E N; Spear, J F (1996) Effect of coronary perfusion of heptanol on conduction and ventricular arrhythmias in infarcted canine myocardium. J Cardiovasc Electrophysiol 7:1159-71
Hanich, R F; Levine, J H; Prood, C et al. (1993) Electrophysiologic recovery in postischemic, stunned myocardium despite persistent systolic dysfunction. Am Heart J 125:23-32
Callans, D J; Kieval, R S; Hook, B G et al. (1992) Effect of coronary perfusion of heptanol or potassium on conduction and ventricular arrhythmias. Am J Physiol 263:H1382-9
Kieval, R S; Spear, J F; Moore, E N (1992) Gap junctional conductance in ventricular myocyte pairs isolated from postischemic rabbit myocardium. Circ Res 71:127-36
Kadish, A; Balke, C W; Levine, J F et al. (1989) Activation patterns in healed experimental myocardial infarction. Circ Res 65:1698-709
Levine, J H; Moore, E N; Kadish, A H et al. (1988) Mechanisms of depressed conduction from long-term amiodarone therapy in canine myocardium. Circulation 78:684-91
Moore, E N; Spear, J F (1988) Electrophysiologic studies on ventricular tachyarrhythmias in a chronic canine infarct model. J Electrocardiol 21 Suppl:S64-7
Levine, J H; Merillat, J C; Stern, M et al. (1987) The cellular electrophysiologic changes induced by ablation: comparison between argon laser photoablation and high-energy electrical ablation. Circulation 76:217-25
Levine, J H; Moore, E N; Weisman, H F et al. (1987) Depression of action potential characteristics and a decreased space constant are present in postischemic, reperfused myocardium. J Clin Invest 79:107-16

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