This proposal will examine the hypothesis that comprehensive mapping of endocardial and epicardial monophasic action potential distribution will permit accurate prediction of body surface potential maps during QRST. It will also examine the alternate hypothesis that failures of prediction stem primarily from intramural effects of anisotropy of heart muscle, inhomogeneity of the volume conduction. The data collected will include serial monophasic action potential maps of endocardial and epicardial surfaces, body surface potential maps, experimentally determined transfer coefficients from heart-to-skin. The analysis will include the construction of models of the heart-in-torso, of comparing alternative methods of information transfer between heart surface and body surface, and of combining these approaches to provide serial instantaneous display of the heart's electrical activity in image form. Better understanding of the mixture and integration of the flow of information (electrical signal) from the heart to the body surface may provide the proper critical background for subsequent revision of diagnostic systems based on surface pattern analysis. Organization of the surface phase relationships under normal and common abnormal conditions provide the matrix upon which a dynamic image of the probable electrical state of the ventricular wall may be built; such a display - especially when correlated with other cardiac imaging techniques - should accelerate accumulation of insight into the relationship between electrical and mechanical cardiac function.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
2R01HL033715-03A3
Application #
3345846
Study Section
(SSS)
Project Start
1984-07-01
Project End
1994-06-30
Budget Start
1989-07-01
Budget End
1990-06-30
Support Year
3
Fiscal Year
1989
Total Cost
Indirect Cost
Name
Medical College of Georgia (MCG)
Department
Type
Schools of Medicine
DUNS #
City
Augusta
State
GA
Country
United States
Zip Code
30912