The goal of the proposed research program is the complete characterisation of synthetic compounds which are models for the oxygen carrying hemoproteins. This program of research will elucidate the redox reactivity of deoxyhemoglobin and deoxymyoglobin model compounds possessing central metal ions which remain five coordinate upon electron transfer. The desired coordination geometry of the central metal ions will be controlled via steric encumberance synthetically built onto only one side of the porphyrin. These model compounds will then be reacted with CO, CS, CSe (the later two created in situ) to form six coordinate metalloporphyrins in which the diatomic ligand resides in a hydrophobic cavity. The redox reactivity of these compounds will be characterized by careful voltammetric and spectroelectrochemical experiments.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
1R01HL033734-01
Application #
3345893
Study Section
Metallobiochemistry Study Section (BMT)
Project Start
1985-09-15
Project End
1988-09-14
Budget Start
1985-09-15
Budget End
1986-09-14
Support Year
1
Fiscal Year
1985
Total Cost
Indirect Cost
Name
Georgia Institute of Technology
Department
Type
Schools of Arts and Sciences
DUNS #
097394084
City
Atlanta
State
GA
Country
United States
Zip Code
30332