Oxidant-Induced Pulmonary Injury in Neonates

Roberts, Robert John

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Heart, Lung, and Blood Institute (NHLBI)
• Type: Research Project (R01)
• Project #: 1R01HL033964-01A2
• Application #: 3346409
• Study Section: Respiratory and Applied Physiology Study Section (RAP)
• Project Start: 1986-12-01
• Project End: 1987-06-30
• Budget Start: 1986-12-01
• Budget End: 1987-06-30
• Support Year: 1
• Fiscal Year: 1987

Institution

• Name: University of Iowa
• Type: Schools of Medicine
• DUNS #: 041294109
• City: Iowa City
• State: IA
• Country: United States
• Zip Code: 52242

Publications

Sullivan, S J; Oberley, T D; Roberts, R J et al. (1992) A stable O2-resistant cell line: role of lipid peroxidation byproducts in O2-mediated injury. Am J Physiol 262:L748-56

Spitz, D R; Adams, D T; Sherman, C M et al. (1992) Mechanisms of cellular resistance to hydrogen peroxide, hyperoxia, and 4-hydroxy-2-nonenal toxicity: the significance of increased catalase activity in H2O2-resistant fibroblasts. Arch Biochem Biophys 292:221-7

Spitz, D R; Sullivan, S J; Malcolm, R R et al. (1991) Glutathione dependent metabolism and detoxification of 4-hydroxy-2-nonenal. Free Radic Biol Med 11:415-23

Sullivan, S J; Roberts, R J; Spitz, D R (1991) Replacement of media in cell culture alters oxygen toxicity: possible role of lipid aldehydes and glutathione transferase in oxygen toxicity. J Cell Physiol 147:427-33

Spitz, D R; Malcolm, R R; Roberts, R J (1990) Cytotoxicity and metabolism of 4-hydroxy-2-nonenal and 2-nonenal in H2O2-resistant cell lines. Do aldehydic by-products of lipid peroxidation contribute to oxidative stress? Biochem J 267:453-9

Spitz, D R; Elwell, J H; Sun, Y et al. (1990) Oxygen toxicity in control and H2O2-resistant Chinese hamster fibroblast cell lines. Arch Biochem Biophys 279:249-60