Abstract

In the present project the influence of cyclic nucleotides (cAMP and cGMP) on the cell diffusion of Lucifer Yellow CH in mammalian cardiac fibers will be investigated. For this, the cut-end method will be used. Our main objective is to elucidate the possible role of cyclic nucleotides on the physiological regulation of junctional permeability in cardiac fibers. As many hormones, such as epinephrine and glucagon enhance the intracellular concentration of cAMP in heart cells it is possible to visualize that part of the hormonal action is related to an increase in the exchange of ions and molecules between heart cells. It is extremely important to know how the junctional permeability is regulated under physiological conditions because impairment of electrical synchronization and conduction in heart muscle can be visualized as a natural consequence of a change in junctional conductance.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL034148-02
Application #
3346791
Study Section
Cardiovascular Study Section (CVA)
Project Start
1985-12-01
Project End
1989-09-30
Budget Start
1986-12-01
Budget End
1989-09-30
Support Year
2
Fiscal Year
1987
Total Cost
Indirect Cost

  Institution

Name
University of Puerto Rico Med Sciences
Department
Type
Schools of Medicine
DUNS #
City
San Juan
State
PR
Country
United States
Zip Code
00936

  Publications

De Mello, W C; Gerena, Y (2010) Further studies on the effects of intracrine and extracellular angiotensin II on the regulation of heart cell volume. On the influence of aldosterone and spironolactone. Regul Pept 165:200-5
De Mello, Walmor C (2009) Cell swelling, impulse conduction, and cardiac arrhythmias in the failing heart. Opposite effects of angiotensin II and angiotensin (1-7) on cell volume regulation. Mol Cell Biochem 330:211-7
De Mello, Walmor C (2006) On the pathophysiological implications of an intracellular renin receptor. Circ Res 99:1285-6
De Mello, Walmor C (2006) Renin increments the inward calcium current in the failing heart. J Hypertens 24:1181-6
De Mello, Walmor C; Specht, Philip (2006) Chronic blockade of angiotensin II AT1-receptors increased cell-to-cell communication, reduced fibrosis and improved impulse propagation in the failing heart. J Renin Angiotensin Aldosterone Syst 7:201-5
Kurdi, Mazen; De Mello, Walmor C; Booz, George W (2005) Working outside the system: an update on the unconventional behavior of the renin-angiotensin system components. Int J Biochem Cell Biol 37:1357-67
De Mello, Walmor C; Monterrubio, Jose (2004) Intracellular and extracellular angiotensin II enhance the L-type calcium current in the failing heart. Hypertension 44:360-4
De Mello, Walmor C (2004) Heart failure: how important is cellular sequestration? The role of the renin-angiotensin-aldosterone system. J Mol Cell Cardiol 37:431-8
De Mello, Walmor (2003) Effect of extracellular and intracellular angiotensins on heart cell function; on the cardiac renin-angiotensin system. Regul Pept 114:87-90
De Mello, Walmor C (2002) Aldosterone modulates the effect of angiotensin II on the electrical properties of rat heart. J Cardiovasc Pharmacol 40:90-5

Showing the most recent 10 out of 39 publications