The proposal intends to determine whether intravascular volume changes occur in selected regions of the capacitance vasculature and whether cardiac output is altered subsequent to the regional volume changes during various interventions in intact organisms.
These aims are consistent with the applicant's long term objective to examine the influence of hemodynamic alterations in the capacitance vasculature on overall circulatory performance. Such an examination is important since many pathologic conditions and therapeutic interventions may influence circulatory function by means of effects on the capacitance circulation. This proposal will examine the influence of selective adrenergic and cholingeric receptor stimulation; administration of ouabain, verapamil, nitroglycerin, and naloxone; and the initiation of autonomic reflex phenomena on regional capacitance volume in intact anesthetized dogs, conscious dogs, and normal human subjects. Splanchnic, limb, and pulmonary blood volume changes will be measured by quantitative radionuclide imaging and plethysmography. It is expected that the total peripheral volume response will be determined mostly by the splanchnic volume response. Thus, the extent to which splanchnic volume changes are due to direct effects on the splanchnic capacitance vessels as opposed to changes in splanchnic inflow and right atrial pressure will be determined. Furthermore, whether the splanchnic volume response causes a change in cardiac output and the extent to which this influence is modified by changes in systemic arterial pressure, cardiac contractility, and heart rate will be ascertained. Finally, whether pulmonary blood volume is changed subseqent to the splanchnic response or subsequent to direct actions of the interventions on the pulmonary circulation will be determined. Thus, these studies should demonstrate the extent to which capacitance volume changes influence circulatory function during various physiologic and therapeutic interventions.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL034204-05
Application #
3346935
Study Section
Experimental Cardiovascular Sciences Study Section (ECS)
Project Start
1985-04-01
Project End
1991-03-31
Budget Start
1989-04-01
Budget End
1991-03-31
Support Year
5
Fiscal Year
1989
Total Cost
Indirect Cost
Name
Yale University
Department
Type
Schools of Medicine
DUNS #
082359691
City
New Haven
State
CT
Country
United States
Zip Code
06520
Morse, M A; Rutlen, D L (1994) Influence of nitroglycerin on splanchnic capacity and splanchnic capacity-cardiac output relationship. J Appl Physiol 76:112-9
Rutlen, D L; Welt, F G; Ilebekk, A (1992) Passive effect of reduced cardiac function on splanchnic intravascular volume. Am J Physiol 262:H1361-4
Bell, L; Zaret, B L; Rutlen, D L (1991) Influence of alpha-adrenergic receptor stimulation on splanchnic intravascular volume in conscious humans. Acta Physiol Scand 143:65-9
Welt, F G; Rutlen, D L (1991) Effect of vasopressin on systemic capacity. Am J Physiol 261:H1494-8
Schulman, D S; Biondi, J W; Bell, L et al. (1991) Hemodynamic effects of 1:2 ECG-coupled jet ventilation in the dog. A comparison with other modes. Am Rev Respir Dis 144:819-25
Chang, P I; Rutlen, D L (1991) Effects of beta-adrenergic agonists on splanchnic vascular volume and cardiac output. Am J Physiol 261:H1499-507
Bell, L; Rutlen, D L (1990) Quantitative radionuclide assessment of total pulmonary vascular volume changes. Can J Physiol Pharmacol 68:727-32
Rutlen, D L; Christensen, G; Helgesen, K G et al. (1990) Influence of atrial natriuretic factor on intravascular volume displacement in pigs. Am J Physiol 259:H1595-600
Hedberg, P A; Rutlen, D L (1990) Influence of serotonin on total intravascular capacity in the anaesthetized dog. Acta Physiol Scand 139:561-8
Rutlen, D L; Helgesen, K G; Christensen, G et al. (1990) Influence of angiotensin on total intravascular capacity in the anaesthetized pig. Acta Physiol Scand 139:569-73

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