Abstract

Employing the concept of an incremental modulus, a model is nearing completion for the quantitation of stiffness-stress relations throughout the diastolic period. This model forms the basis for studying the importance of effects such as external constraints, muscle elasticity incomplete relaxation etc. in the determination of the diastolic pressure-volume relations following drug intervention and pacing induced angina. Clinical studies are being continued relative to the problem of predicting post-operative performance in valvular heart disease and in particular, the question of the relationship between diastolic and systolic function is to be addressed.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
7R01HL034596-01
Application #
3347670
Study Section
Cardiovascular Study Section (CVA)
Project Start
1984-12-01
Project End
1986-11-30
Budget Start
1984-12-01
Budget End
1986-11-30
Support Year
1
Fiscal Year
1985
Total Cost
Indirect Cost

  Institution

Name
Brigham and Women's Hospital
Department
Type
DUNS #
071723621
City
Boston
State
MA
Country
United States
Zip Code

  Publications

Mirsky, I; Aoyagi, T; Ihara, T et al. (1995) Contractile state is the major determinant of functional outcome in patients with left ventricular dysfunction treated with enalapril. Eur Heart J 16:808-17
Aoyagi, T; Pouleur, H; Van Eyll, C et al. (1993) Wall motion asynchrony is a major determinant of impaired left ventricular filling in patients with healed myocardial infarction. Am J Cardiol 72:268-72
Aoyagi, T; Fujii, A M; Flanagan, M F et al. (1993) Transition from compensated hypertrophy to intrinsic myocardial dysfunction during development of left ventricular pressure-overload hypertrophy in conscious sheep. Systolic dysfunction precedes diastolic dysfunction. Circulation 88:2415-25
Aoyagi, T; Fujii, A M; Colan, S D et al. (1992) Different responses of extent and velocity of contraction to dobutamine in conscious sheep. Am J Physiol 263:H1250-61
Aoyagi, T; Mirsky, I; Flanagan, M F et al. (1992) Myocardial function in immature and mature sheep with pressure-overload hypertrophy. Am J Physiol 262:H1036-48
Aoyagi, T; Momomura, S; Matsui, H et al. (1991) Myocardial contractility and contraction duration are unrelated in the left ventricle with moderate pressure-overload hypertrophy. Jpn Heart J 32:111-30
Parker, J D; Landzberg, J S; Bittl, J A et al. (1991) Effects of beta-adrenergic stimulation with dobutamine on isovolumic relaxation in the normal and failing human left ventricle. Circulation 84:1040-8
Mirsky, I; Pasipoularides, A (1990) Clinical assessment of diastolic function. Prog Cardiovasc Dis 32:291-318
Mirsky, I; Aoyagi, T; Crocker, V M et al. (1990) Preload dependence of fiber shortening rate in conscious dogs with left ventricular hypertrophy. J Am Coll Cardiol 15:890-9
Aoyagi, T; Fujii, A M; Gelpi, R J et al. (1990) Application of the systolic stiffness concept to assess myocardial function in developing hypertension. Jpn Heart J 31:71-85

Showing the most recent 10 out of 15 publications