This proposal is for the renewal for Phase I of the Treatment of """"""""Mild"""""""" Hypertension Study (T0MHS). The study will allow for long-term detailed assessment of 902 hypertensives prescribed one of five active drugs (representing major classes of medications currently in use) or placebo, using a randomized double-blind design. Each treatment group also is advised nonpharmacologic methods to control their blood pressure including weight loss, dietary sodium reduction, alcohol reduction and increased leisure-time physical activity. This proposal is for a 2 year and 7 month continuation which includes 2 additional years of follow-up and a final 7 months for close-out activities, data analysis and publications.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL034767-06
Application #
3348072
Study Section
Special Emphasis Panel (SRC (OK))
Project Start
1990-09-30
Project End
1993-09-29
Budget Start
1991-09-30
Budget End
1993-09-29
Support Year
6
Fiscal Year
1991
Total Cost
Indirect Cost
Name
University of Minnesota Twin Cities
Department
Type
Schools of Public Health
DUNS #
168559177
City
Minneapolis
State
MN
Country
United States
Zip Code
55455
Ganguli, M C; Grimm Jr, R H; Svendsen, K H et al. (1997) Higher education and income are related to a better Na:K ratio in blacks: baseline results of the Treatment of Mild Hypertension Study (TOMHS) data. Am J Hypertens 10:979-84
Grimm Jr, R H; Grandits, G A; Prineas, R J et al. (1997) Long-term effects on sexual function of five antihypertensive drugs and nutritional hygienic treatment in hypertensive men and women. Treatment of Mild Hypertension Study (TOMHS) Hypertension 29:8-14
Grimm Jr, R H; Flack, J M; Grandits, G A et al. (1996) Long-term effects on plasma lipids of diet and drugs to treat hypertension. Treatment of Mild Hypertension Study (TOMHS) Research Group. JAMA 275:1549-56
Lewis, C E; Grandits, A; Flack, J et al. (1996) Efficacy and tolerance of antihypertensive treatment in men and women with stage 1 diastolic hypertension. Results of the Treatment of Mild Hypertension Study. Arch Intern Med 156:377-85
Flack, J M; Neaton, J; Grimm Jr, R et al. (1995) Blood pressure and mortality among men with prior myocardial infarction. Multiple Risk Factor Intervention Trial Research Group. Circulation 92:2437-45
Elmer, P J; Grimm Jr, R; Laing, B et al. (1995) Lifestyle intervention: results of the Treatment of Mild Hypertension Study (TOMHS). Prev Med 24:378-88
Grandits, G A; Liebson, P R; Dianzumba, S et al. (1994) Echocardiography in multicenter clinical trials: experience from the Treatment of Mild Hypertension Study. Control Clin Trials 15:395-410
Bradley, K; Flack, J M; Belcher, J et al. (1993) Chlorthalidone attenuates the reduction in total cholesterol and small, dense LDL cholesterol subclass associated with weight loss. Am J Hypertens 6:636-9
Flack, J M; Neaton, J D; Daniels, B et al. (1993) Ethnicity and renal disease: lessons from the Multiple Risk Factor Intervention Trial and the Treatment of Mild Hypertension Study. Am J Kidney Dis 21:31-40
Neaton, J D; Grimm Jr, R H; Prineas, R J et al. (1993) Treatment of Mild Hypertension Study. Final results. Treatment of Mild Hypertension Study Research Group. JAMA 270:713-24

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