Cystic fibrosis is the most common inherited life-shortening disease among white populations and is characterized by progressive loss of pulmonary function and exercise tolerance. We have previously shown that exercise programs can increase fitness in these patients, but without apparent effect on lung function. Others have shown improvement in pulmonary function with activity programs but have not examined fitness in patients with cystic fibrosis. No studies have examined the effect that activity programs may have on the quality of well-being in these patients, nor have there ben appropriately controlled long-term studies. We plan to institute a two year at-home activity program which will substantially increase the patients level of habitual activity. Behavioral medicine techniques will be used to promote compliance to this two year program. Fifty patients will be randomly assigned to the activity program and fifty patients to a non-exercise control group. We will examine the effects of this program on pulmonary function, exercise tolerance and quality of well-being of the treatment group compared to the control group. We will also determine if any relationship exists among physical activity (as quantified by two activity monitors and activity surveys) and pulmonary function, cardiopulmonary testing and quality of well- being.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
1R01HL035334-01A3
Application #
3349135
Study Section
(SRC)
Project Start
1988-09-01
Project End
1992-08-31
Budget Start
1988-09-01
Budget End
1989-08-31
Support Year
1
Fiscal Year
1988
Total Cost
Indirect Cost
Name
Children's Hosp Pittsburgh/Upmc Health Sys
Department
Type
DUNS #
044304145
City
Pittsburgh
State
PA
Country
United States
Zip Code
15224
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Orenstein, D M; Curtis, S E; Nixon, P A et al. (1993) Accuracy of three pulse oximeters during exercise and hypoxemia in patients with cystic fibrosis. Chest 104:1187-90
Nixon, P A; Orenstein, D M; Kelsey, S F et al. (1992) The prognostic value of exercise testing in patients with cystic fibrosis. N Engl J Med 327:1785-8
Orenstein, D M; Nixon, P A (1991) Exercise performance and breathing patterns in cystic fibrosis: male-female differences and influence of resting pulmonary function. Pediatr Pulmonol 10:101-5
Orenstein, D M; Kaplan, R M (1991) Measuring the quality of well-being in cystic fibrosis and lung transplantation. The importance of the area under the curve. Chest 100:1016-8
Nixon, P A; Orenstein, D M; Curtis, S E et al. (1990) Oxygen supplementation during exercise in cystic fibrosis. Am Rev Respir Dis 142:807-11