Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
3R01HL036014-11S1
Application #
873158
Study Section
Pharmacology A Study Section (PHRA)
Project Start
1985-07-01
Project End
1997-06-30
Budget Start
1995-07-01
Budget End
1996-06-30
Support Year
11
Fiscal Year
1995
Total Cost
Indirect Cost
Name
Brigham and Women's Hospital
Department
Type
DUNS #
071723621
City
Boston
State
MA
Country
United States
Zip Code
02115
Gadbut, A P; Wu, L; Tang, D et al. (1997) Induction of the cholesterol metabolic pathway regulates the farnesylation of RAS in embryonic chick heart cells: a new role for ras in regulating the expression of muscarinic receptors and G proteins. EMBO J 16:7250-60
Gadbut, A P; Riccardi, D; Wu, L et al. (1996) Specificity of coupling of muscarinic receptor isoforms to a novel chick inward-rectifying acetylcholine-sensitive K+ channel. J Biol Chem 271:6398-402
Loh, E; Barnett, J V; Feldman, A M et al. (1995) Decreased adenylate cyclase activity and expression of Gs alpha in human myocardium after orthotopic cardiac transplantation. Circ Res 76:852-60
Kilbourne, E J; Galper, J B (1994) Isolation and expression of a novel chick G-protein cDNA coding for a G alpha i3 protein with a G alpha 0 N-terminus. Biochem J 297 ( Pt 2):303-8
Gadbut, A P; Toupin, D K; Kilbourne, E J et al. (1994) Low density lipoproteins induce parasympathetic responsiveness in embryonic chick ventricular myocytes in parallel with a coordinate increase in expression of genes coding for the M2 muscarinic receptor, G alpha i2, and the acetylcholine-sensitive K+ chan J Biol Chem 269:30707-12
Kilbourne, E J; Galper, J B (1994) Cloning of cDNAs coding for the G alpha i1 and G alpha i2 G-proteins from chick brain. Gene 150:341-4
Gadbut, A P; Galper, J B (1994) A novel M3 muscarinic acetylcholine receptor is expressed in chick atrium and ventricle. J Biol Chem 269:25823-9
Barnett, J V; Taniuchi, M; Yang, M B et al. (1993) Co-culture of embryonic chick heart cells and ciliary ganglia induces parasympathetic responsiveness in embryonic chick heart cells. Biochem J 292 ( Pt 2):395-9
Tan, W; Barnett, J V; Pietrobon, D et al. (1993) Effect of low-density lipoproteins, mevinolin, and G proteins on Ca2+ response in cultured chick atrial cells. Am J Physiol 265:H191-7
Barnett, J V; Shamah, S M; Lassegue, B et al. (1990) Development of muscarinic-cholinergic stimulation of inositol phosphate production in cultured embryonic chick atrial cells. Evidence for a switch in guanine-nucleotide-binding protein coupling. Biochem J 271:443-8

Showing the most recent 10 out of 12 publications