Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
7R01HL037936-01
Application #
3353882
Study Section
Metabolism Study Section (MET)
Project Start
1986-04-01
Project End
1990-09-29
Budget Start
1986-04-01
Budget End
1986-09-29
Support Year
1
Fiscal Year
1985
Total Cost
Indirect Cost
Name
Geisinger Medical Center
Department
Type
DUNS #
City
Danville
State
PA
Country
United States
Zip Code
17822
Karmazyn, M; Tani, M; Neely, J R (1993) Effect of prostaglandins I2 (prostacyclin) and F2 alpha on function, energy metabolism, and calcium uptake in ischaemic/reperfused hearts. Cardiovasc Res 27:396-402
Tani, M; Neely, J R (1991) Deleterious effects of digitalis on reperfusion-induced arrhythmias and myocardial injury in ischemic rat hearts: possible involvements of myocardial Na+ and Ca2+ imbalance. Basic Res Cardiol 86:340-54
Morgan, H E; Baker, K M (1991) Cardiac hypertrophy. Mechanical, neural, and endocrine dependence. Circulation 83:13-25
Tani, M; Neely, J R (1990) Na+ accumulation increases Ca2+ overload and impairs function in anoxic rat heart. J Mol Cell Cardiol 22:57-72
Tani, M (1990) Mechanisms of Ca2+ overload in reperfused ischemic myocardium. Annu Rev Physiol 52:543-59
Tani, M (1990) Effects of anti-free radical agents on Na+, Ca2+, and function in reperfused rat hearts. Am J Physiol 259:H137-43
Tani, M; Neely, J R (1990) Intermittent perfusion of ischemic myocardium. Possible mechanisms of protective effects on mechanical function in isolated rat heart. Circulation 82:536-48
Tani, M; Neely, J R (1990) Vascular washout reduces Ca2+ overload and improves function of reperfused ischemic hearts. Am J Physiol 258:H354-61
Tani, M; Neely, J R (1990) Mechanisms of reduced reperfusion injury by low Ca2+ and/or high K+. Am J Physiol 258:H1025-31
Tani, M; Neely, J R (1989) Role of intracellular Na+ in Ca2+ overload and depressed recovery of ventricular function of reperfused ischemic rat hearts. Possible involvement of H+-Na+ and Na+-Ca2+ exchange. Circ Res 65:1045-56

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