Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
7R01HL038292-07
Application #
3354477
Study Section
Hematology Subcommittee 2 (HEM)
Project Start
1987-07-01
Project End
1996-06-30
Budget Start
1993-03-01
Budget End
1993-06-30
Support Year
7
Fiscal Year
1992
Total Cost
Indirect Cost
Name
Cleveland Clinic Lerner
Department
Type
DUNS #
017730458
City
Cleveland
State
OH
Country
United States
Zip Code
44195
Suehiro, K; Gailit, J; Plow, E F (1997) Fibrinogen is a ligand for integrin alpha5beta1 on endothelial cells. J Biol Chem 272:5360-6
Zhang, L; Plow, E F (1996) A discrete site modulates activation of I domains. Application to integrin alphaMbeta2. J Biol Chem 271:29953-7
Suehiro, K; Smith, J W; Plow, E F (1996) The ligand recognition specificity of beta3 integrins. J Biol Chem 271:10365-71
Zhang, L; Plow, E F (1996) Overlapping, but not identical, sites are involved in the recognition of C3bi, neutrophil inhibitory factor, and adhesive ligands by the alphaMbeta2 integrin. J Biol Chem 271:18211-6
Ugarova, T P; Ljubimov, A V; Deng, L et al. (1996) Proteolysis regulates exposure of the IIICS-1 adhesive sequence in plasma fibronectin. Biochemistry 35:10913-21
Haas, T A; Plow, E F (1996) The cytoplasmic domain of alphaIIb beta3. A ternary complex of the integrin alpha and beta subunits and a divalent cation. J Biol Chem 271:6017-26
Ugarova, T P; Zamarron, C; Veklich, Y et al. (1995) Conformational transitions in the cell binding domain of fibronectin. Biochemistry 34:4457-66
Cierniewski, C S; Haas, T A; Smith, J W et al. (1994) Characterization of cation-binding sequences in the platelet integrin GPIIb-IIIa (alpha IIb beta 3) by terbium luminescence. Biochemistry 33:12238-46
D'Souza, S E; Haas, T A; Piotrowicz, R S et al. (1994) Ligand and cation binding are dual functions of a discrete segment of the integrin beta 3 subunit: cation displacement is involved in ligand binding. Cell 79:659-67
Muchowski, P J; Zhang, L; Chang, E R et al. (1994) Functional interaction between the integrin antagonist neutrophil inhibitory factor and the I domain of CD11b/CD18. J Biol Chem 269:26419-23

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