The proposed research is designed to test the ability of a skeletal muscle-powered (rectus abdominis) assist ventricle to augment cardiac output in a chronic study in dogs. The research is based upon a series of studies performed in our laboratory and elsewhere that have demonstrated the feasibility of skeletal muscle powered circulatory assistance. The optimum conduit design in which selected skeletal muscles would most efficiently assist the circulation has not been determined, and the problems of muscle fatigue and lack of a suitable pulse generator to stimulate and coordinate skeletal muscle work are limitations to existing assist systems. The proposed research is divided into 3 separate studies which address these limitations. First we will compare 3 different regimens for converting untrained rectus abdominis muscle to a fatigue-resistant muscle without loss of strength. Feasibility data that show electrically stimulated tetanic contractions against a compressible pouch, at rates of 6-90/min, may prevent muscle injury and optimize muscle conditioning. Second, we will extend preliminary work on a custom designed pulse generator that can sense cardiac activity and be programmed to deliver a specific stimulus. Such a device would have multiple leads delivering a constant current pulse and would be powerful enough to chronically stimulate tetanic muscle contractions via the motor nerve in our rectus ventricle assist system. Third, we will combine our earlier findings, the findings of other investigators, and the results of proposed studies to determine the effectiveness of the rectus assist ventricle for chronically augmenting cardiac output in dogs. The results of this research will provide essential data for future clinical trials of this promising treatment modality for intractable chronic heart failure.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL039724-03
Application #
3356582
Study Section
Surgery and Bioengineering Study Section (SB)
Project Start
1988-07-01
Project End
1991-06-30
Budget Start
1990-07-01
Budget End
1991-06-30
Support Year
3
Fiscal Year
1990
Total Cost
Indirect Cost
Name
Purdue University
Department
Type
Schools of Engineering
DUNS #
072051394
City
West Lafayette
State
IN
Country
United States
Zip Code
47907
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Herbert, S T; Badylak, S F; Geddes, L A et al. (1993) Elastic modulus of prepared canine jejunum, a new vascular graft material. Ann Biomed Eng 21:727-33
Geddes, L A; Badylak, S F; Tacker, W A et al. (1992) Output power and metabolic input power of skeletal muscle contracting linearly to compress a pouch in a mock circulatory system. J Thorac Cardiovasc Surg 104:1435-42
Geddes, L A; Janas, W; Badylak, S F (1992) Use of impedance ratio for the continuous measurement of stroke volume of a valveless pouch used as a cardiac-assist device. IEEE Trans Biomed Eng 39:310-3
Badylak, S F; Wessale, J E; Geddes, L A et al. (1992) The effect of skeletal muscle ventricle pouch pressure on muscle blood flow. ASAIO J 38:66-71
Geddes, L A; Badylak, S F (1991) Power capability of skeletal muscle to pump blood. ASAIO Trans 37:19-23
Wessale, J L; Geddes, L A; Badylak, S F et al. (1991) Pumping capabilities of the latissimus dorsi and rectus abdominis muscles wrapped around a valved pouch in a mock circulatory system. ASAIO Trans 37:615-9
Wessale, J L; Geddes, L A; Badylak, S F et al. (1991) Use of electrical impedance for continuous measurement of stroke volume of a skeletal muscle-powered cardiac assist device. Med Biol Eng Comput 29:207-11
Geddes, L A; Wessale, J L; Badylak, S F et al. (1990) The use of an electrically activated valve to control preload and provide maximal muscle blood flow with a skeletal-muscle ventricle. Pacing Clin Electrophysiol 13:783-95
Voytik, S L; Babbs, C F; Badylak, S F (1990) Simple electrical model of the circulation to explore design parameters for a skeletal muscle ventricle. J Heart Transplant 9:160-74

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