Pathogenetic Mechanisms in Diabetic Vascular Disease

Williamson, Joseph R.

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Heart, Lung, and Blood Institute (NHLBI)
• Type: Research Project (R01)
• Project #: 5R01HL039934-09
• Application #: 2219458
• Study Section: Metabolism Study Section (MET)
• Project Start: 1988-03-01
• Project End: 1997-02-28
• Budget Start: 1996-03-01
• Budget End: 1997-02-28
• Support Year: 9
• Fiscal Year: 1996

Institution

• Name: Washington University
• Department: Pathology
• Type: Schools of Medicine
• DUNS #: 062761671
• City: Saint Louis
• State: MO
• Country: United States
• Zip Code: 63130

Publications

Ido, Yasuo; Nyengaard, Jens R; Chang, Kathy et al. (2010) Early neural and vascular dysfunctions in diabetic rats are largely sequelae of increased sorbitol oxidation. Antioxid Redox Signal 12:39-51

Shao, Baohai; Fu, Xiaoyun; McDonald, Thomas O et al. (2005) Acrolein impairs ATP binding cassette transporter A1-dependent cholesterol export from cells through site-specific modification of apolipoprotein A-I. J Biol Chem 280:36386-96

Pennathur, Subramaniam; Ido, Yasuo; Heller, Jozsef I et al. (2005) Reactive carbonyls and polyunsaturated fatty acids produce a hydroxyl radical-like species: a potential pathway for oxidative damage of retinal proteins in diabetes. J Biol Chem 280:22706-14

Ido, Yasuo; Chang, Katherine; Williamson, Joseph R (2004) NADH augments blood flow in physiologically activated retina and visual cortex. Proc Natl Acad Sci U S A 101:653-8

Nyengaard, Jens R; Ido, Yassuo; Kilo, Charles et al. (2004) Interactions between hyperglycemia and hypoxia: implications for diabetic retinopathy. Diabetes 53:2931-8

Ido, Y; Chang, K C; Lejeune, W S et al. (2001) Vascular dysfunction induced by AGE is mediated by VEGF via mechanisms involving reactive oxygen species, guanylate cyclase, and protein kinase C. Microcirculation 8:251-63

Schmidt, R E; Dorsey, D A; Beaudet, L N et al. (2001) Inhibition of sorbitol dehydrogenase exacerbates autonomic neuropathy in rats with streptozotocin-induced diabetes. J Neuropathol Exp Neurol 60:1153-69

Tilton, R G; Chang, K C; LeJeune, W S et al. (1999) Role for nitric oxide in the hyperpermeability and hemodynamic changes induced by intravenous VEGF. Invest Ophthalmol Vis Sci 40:689-96

Stephan, C C; Chang, K C; LeJeune, W et al. (1998) Role for heparin-binding growth factors in glucose-induced vascular dysfunction. Diabetes 47:1771-8

Nyengaard, J R; Chang, K; Berhorst, S et al. (1997) Discordant effects of guanidines on renal structure and function and on regional vascular dysfunction and collagen changes in diabetic rats. Diabetes 46:94-106