Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL039948-07
Application #
2219465
Study Section
Hematology Subcommittee 2 (HEM)
Project Start
1988-07-01
Project End
1997-02-28
Budget Start
1993-12-01
Budget End
1997-02-28
Support Year
7
Fiscal Year
1994
Total Cost
Indirect Cost

  Institution

Name
Medical College of Georgia (MCG)
Department
Biochemistry
Type
Schools of Medicine
DUNS #
City
Augusta
State
GA
Country
United States
Zip Code
30912

  Publications

Ling, Jianhua; Baibakov, Boris; Pi, Wenhu et al. (2005) The HS2 enhancer of the beta-globin locus control region initiates synthesis of non-coding, polyadenylated RNAs independent of a cis-linked globin promoter. J Mol Biol 350:883-96
Ling, Jianhua; Ainol, Lincoyan; Zhang, Ling et al. (2004) HS2 enhancer function is blocked by a transcriptional terminator inserted between the enhancer and the promoter. J Biol Chem 279:51704-13
Ling, Jianhua; Pi, Wenhu; Yu, Xiuping et al. (2003) The ERV-9 LTR enhancer is not blocked by the HS5 insulator and synthesizes through the HS5 site non-coding, long RNAs that regulate LTR enhancer function. Nucleic Acids Res 31:4582-96
Ling, Jianhua; Pi, Wenhu; Bollag, Roni et al. (2002) The solitary long terminal repeats of ERV-9 endogenous retrovirus are conserved during primate evolution and possess enhancer activities in embryonic and hematopoietic cells. J Virol 76:2410-23
Ramchandran, R; Bengra, C; Whitney, B et al. (2000) A (GATA)(7) motif located in the 5' boundary area of the human beta-globin locus control region exhibits silencer activity in erythroid cells. Am J Hematol 65:14-24
Migliaccio, A R; Bengra, C; Ling, J et al. (2000) Stable and unstable transgene integration sites in the human genome: extinction of the Green Fluorescent Protein transgene in K562 cells. Gene 256:197-214
Long, Q; Bengra, C; Li, C et al. (1998) A long terminal repeat of the human endogenous retrovirus ERV-9 is located in the 5' boundary area of the human beta-globin locus control region. Genomics 54:542-55
Cavallesco, R; Tuan, D (1997) Modulatory subdomains of the HS2 enhancer differentially regulate enhancer activity in erythroid cells at different developmental stages. Blood Cells Mol Dis 23:8-26
Kong, S; Bohl, D; Li, C et al. (1997) Transcription of the HS2 enhancer toward a cis-linked gene is independent of the orientation, position, and distance of the enhancer relative to the gene. Mol Cell Biol 17:3955-65
Yoo, J; Herman, L E; Li, C et al. (1996) Dynamic changes in the locus control region of erythroid progenitor cells demonstrated by polymerase chain reaction. Blood 87:2558-67

Showing the most recent 10 out of 14 publications